Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

Toshio Ogura; Kiyoshi Morita; Mamoru Takeuchi; Fumio Otsuka; Tatsuo Iwasaki; Katsunori Oe; Kazuharu Matsuura; Kazuo Tobe; Yukari Mimura; Masayuki Kishida; Hirofumi Makino; Masahisa Hirakawa

doi:10.1159/000067933

Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

Toshio Ogura, Kiyoshi Morita, Mamoru Takeuchi, Fumio Otsuka, Tatsuo Iwasaki, Katsunori Oe, Kazuharu Matsuura, Kazuo Tobe, Yukari Mimura, Masayuki Kishida, Hirofumi Makino, Masahisa Hirakawa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	Hormone Research
Volume	59
Issue number	1
DOIs	https://doi.org/10.1159/000067933
Publication status	Published - 2003

Keywords

Adrenomedullin
Anesthesia
Aquaporin 2
Atrial natriuretic peptide
Osmolality
Vasopressin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000067933

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title = "Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia",

abstract = "Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.",

keywords = "Adrenomedullin, Anesthesia, Aquaporin 2, Atrial natriuretic peptide, Osmolality, Vasopressin",

author = "Toshio Ogura and Kiyoshi Morita and Mamoru Takeuchi and Fumio Otsuka and Tatsuo Iwasaki and Katsunori Oe and Kazuharu Matsuura and Kazuo Tobe and Yukari Mimura and Masayuki Kishida and Hirofumi Makino and Masahisa Hirakawa",

year = "2003",

doi = "10.1159/000067933",

language = "English",

volume = "59",

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journal = "Hormone Research",

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TY - JOUR

T1 - Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

AU - Ogura, Toshio

AU - Morita, Kiyoshi

AU - Takeuchi, Mamoru

AU - Otsuka, Fumio

AU - Iwasaki, Tatsuo

AU - Oe, Katsunori

AU - Matsuura, Kazuharu

AU - Tobe, Kazuo

AU - Mimura, Yukari

AU - Kishida, Masayuki

AU - Makino, Hirofumi

AU - Hirakawa, Masahisa

PY - 2003

Y1 - 2003

N2 - Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.

AB - Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.

KW - Adrenomedullin

KW - Anesthesia

KW - Aquaporin 2

KW - Atrial natriuretic peptide

KW - Osmolality

KW - Vasopressin

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Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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