Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

Toshio Ogura, Kiyoshi Morita, Mamoru Takeuchi, Fumio Otsuka, Tatsuo Iwasaki, Katsunori Oe, Kazuharu Matsuura, Kazuo Tobe, Yukari Mimura, Masayuki Kishida, Hirofumi Makino, Masahisa Hirakawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalHormone Research
Issue number1
Publication statusPublished - 2003


  • Adrenomedullin
  • Anesthesia
  • Aquaporin 2
  • Atrial natriuretic peptide
  • Osmolality
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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