Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification

Namuun Ganbaatar, Aya Kadota, Takashi Hisamatsu, Shin Ichi Araki, Shinji Kume, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Hiroyoshi Segawa, Ebtehal Salman, Itsuko Miyazawa, Takashi Yamamoto, Yoshihisa Nakagawa, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Aims: The roles of urinary albumin, eGFRcystatin (eGFRcys), and eGFRcreatinine (eGFRcre) in the progression of coronary artery calcification (CAC) remain unclear. Therefore, the present study investigated the relationship between kidney function and CAC progression. Methods: A total of 760 Japanese men aged 40-79 years were enrolled in this population-based study. Kidney function was measured using eGFRcre, eGFRcys, and the urine albumin-to-creatinine ratio. CAC scores were calculated using the Agatston method. CAC progression was defined as an annual increase of >10 Agatston units (AU) among men with 0<CAC<100 AU at baseline, that of >10% among those with CAC ≥ 100 AU, and any progression for those with CAC =0 at baseline. The relative risk (RR) of CAC progression based on kidney function was assessed using a robust Poisson regression model. Results: The mean follow-up period was 4.9 years. CAC progression was detected in 45.8% of participants. Positive associations between CAC progression and albuminuria (>30mg/g) (RR: 1.29; 1.09 to 1.53; p =0.004) and low eGFRcys (<60ml/min/1.73m2) (RR: 1.27; 1.05 to 1.53; p=0.012) remained significant after adjustments for age, the follow-up time, and computerized tomography type. Following further adjustments for hypertension, diabetes mellitus, dyslipidemia, C-reactive protein, and lifestyle factors, CAC progression was associated with albuminuria (RR: 1.20; 1.01 to 1.43; p=0.04) and low eGFRcys (RR: 1.19; 0.99 to 1.43; p=0.066), but not with eGFRcre. Conclusion: CAC progression was associated with albuminuria; however, its relationship with eGFRcys was weakened by adjustments for risk factors.

Original languageEnglish
Pages (from-to)1359-1371
Number of pages13
JournalJournal of atherosclerosis and thrombosis
Volume29
Issue number9
DOIs
Publication statusPublished - 2022

Keywords

  • Coronary artery calcification progression
  • Estimated glomerular filtration rate
  • Urinary albumin

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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