TY - JOUR
T1 - Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men
AU - Kunitomi, M.
AU - Wada, J.
AU - Takahashi, K.
AU - Tsuchiyama, Y.
AU - Mimura, Y.
AU - Hida, K.
AU - Miyatake, N.
AU - Fujii, M.
AU - Kira, S.
AU - Shikata, K.
AU - Makino, H.
N1 - Funding Information:
This study was approved by Ministry of Health, Labour and Welfare, Japan. This research was supported by Health Science Research Grants for ‘Research on Health Services’ from the Ministry of Health, Labour and Welfare, Japan. It was partly supported by Uehara Memorial Foundation, The Naito Foundation, ONO Medical Foundation to J Wada and Uehara Memorial Foundation to H Makino.
PY - 2002
Y1 - 2002
N2 - OBJECTIVE: To investigate whether the changes in IGF-I concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat. DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: One-hundred and twelve Japanese overweight men aged 30-59y (body mass index (BMI) 28.4±2.5 kg/m2) and 33 normal-weight men aged 30-39y (BMI 22.1±l.5 kg/m2) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8±2.8) were further enrolled into a 1 y exercise program. MEASUREMENTS: Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-I at baseline and after 1 y. RESULTS: In 112 overweight subjects at baseline, insulin (10.5±5.0 μU/ml) and leptin (6.4±3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-I (156.8±48.7 μU/ml) significantly and negatively correlated with V area (r= - 0.242, P = 0.0125) and age (r= - 0.192, P = 0.0480). In normal-weight men aged 30-39 y (n = 33) and age-matched subjects (n = 30) selected from the 112 overweight men, the serum IGF-I further tightly correlated with V area (r= - 0.467, P < 0.0001). Visceral fat area and age were independently related to serum IGF-I levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224±2781 to 7898±4141 steps/day) and reduction of BMI (28.8±2.8 to 27.7±2.9). ΔIGF-I significantly correlated with ΔV area (r= - 0.432, P = 0.0009) but not with ΔS area or ΔBMI. CONCLUSION: The present study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention.
AB - OBJECTIVE: To investigate whether the changes in IGF-I concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat. DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: One-hundred and twelve Japanese overweight men aged 30-59y (body mass index (BMI) 28.4±2.5 kg/m2) and 33 normal-weight men aged 30-39y (BMI 22.1±l.5 kg/m2) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8±2.8) were further enrolled into a 1 y exercise program. MEASUREMENTS: Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-I at baseline and after 1 y. RESULTS: In 112 overweight subjects at baseline, insulin (10.5±5.0 μU/ml) and leptin (6.4±3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-I (156.8±48.7 μU/ml) significantly and negatively correlated with V area (r= - 0.242, P = 0.0125) and age (r= - 0.192, P = 0.0480). In normal-weight men aged 30-39 y (n = 33) and age-matched subjects (n = 30) selected from the 112 overweight men, the serum IGF-I further tightly correlated with V area (r= - 0.467, P < 0.0001). Visceral fat area and age were independently related to serum IGF-I levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224±2781 to 7898±4141 steps/day) and reduction of BMI (28.8±2.8 to 27.7±2.9). ΔIGF-I significantly correlated with ΔV area (r= - 0.432, P = 0.0009) but not with ΔS area or ΔBMI. CONCLUSION: The present study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention.
KW - Exercise
KW - Insulin-like growth factor-I (IGF-I)
KW - Visceral fat
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U2 - 10.1038/sj.ijo.0801899
DO - 10.1038/sj.ijo.0801899
M3 - Article
C2 - 11896491
AN - SCOPUS:85047696103
SN - 0307-0565
VL - 26
SP - 361
EP - 369
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 3
ER -
