Repair mechanism of DNA-protein cross-link damage in Escherichia coli.

Toshiaki Nakano; Soh Morishita; Hiroaki Terato; Seung Pil Pack; Keisuke Makino; Hiroshi Ide

doi:10.1093/nass/nrm107

Repair mechanism of DNA-protein cross-link damage in Escherichia coli.

Toshiaki Nakano, Soh Morishita, Hiroaki Terato, Seung Pil Pack, Keisuke Makino, Hiroshi Ide

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

DNA-protein cross-link (DPC) damage is produced by varieties of genotoxic agents such as ionizing radiation, UV light, aldehydes, and some chemotherapeutic compounds. DPCs would be harmful to cells since proteins immobilized on DNA strands could hamper DNA transactions in cells. However, it has not been clarified how DPCs are repaired in cells. In the present study, we prepared DNA substrates containing defined DPCs and tested them for repair enzymes. We also examined the sensitivity of Escherichia coli to DPC-inducing agents.

Original language	English
Pages (from-to)	213-214
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	51
DOIs	https://doi.org/10.1093/nass/nrm107
Publication status	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1093/nass/nrm107

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abstract = "DNA-protein cross-link (DPC) damage is produced by varieties of genotoxic agents such as ionizing radiation, UV light, aldehydes, and some chemotherapeutic compounds. DPCs would be harmful to cells since proteins immobilized on DNA strands could hamper DNA transactions in cells. However, it has not been clarified how DPCs are repaired in cells. In the present study, we prepared DNA substrates containing defined DPCs and tested them for repair enzymes. We also examined the sensitivity of Escherichia coli to DPC-inducing agents.",

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AU - Nakano, Toshiaki

AU - Morishita, Soh

AU - Terato, Hiroaki

AU - Pack, Seung Pil

AU - Makino, Keisuke

AU - Ide, Hiroshi

PY - 2007

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AB - DNA-protein cross-link (DPC) damage is produced by varieties of genotoxic agents such as ionizing radiation, UV light, aldehydes, and some chemotherapeutic compounds. DPCs would be harmful to cells since proteins immobilized on DNA strands could hamper DNA transactions in cells. However, it has not been clarified how DPCs are repaired in cells. In the present study, we prepared DNA substrates containing defined DPCs and tested them for repair enzymes. We also examined the sensitivity of Escherichia coli to DPC-inducing agents.

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Repair mechanism of DNA-protein cross-link damage in Escherichia coli.

Abstract

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