TY - JOUR
T1 - Repair roles of hSMUG1 assessed by damage specificity and cellular activity.
AU - Masaoka, Aya
AU - Matsubara, Mayumi
AU - Tanaka, Tamon
AU - Terato, Hiroaki
AU - Ohyama, Yoshihiko
AU - Kubo, Kihei
AU - Ide, Hiroshi
PY - 2003
Y1 - 2003
N2 - Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA glycosylase (UDG). However, the subsequent studies have shown conflicting results about the substrate specificity of SMUG1. In the present study, to clarify the repair role of SMUG1, we determined the damage specificity of purified human SMUG1 (hSMUG1) and its contribution to repair of oxidized bases in HeLa cell extracts.
AB - Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA glycosylase (UDG). However, the subsequent studies have shown conflicting results about the substrate specificity of SMUG1. In the present study, to clarify the repair role of SMUG1, we determined the damage specificity of purified human SMUG1 (hSMUG1) and its contribution to repair of oxidized bases in HeLa cell extracts.
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U2 - 10.1093/nass/3.1.263
DO - 10.1093/nass/3.1.263
M3 - Article
C2 - 14510481
AN - SCOPUS:0142212258
SP - 263
EP - 264
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 3
ER -