TY - JOUR
T1 - Repetitive questioning behavior in Alzheimer's disease
T2 - Relationship to regional cerebral blood flow
AU - Kishimoto, Yuki
AU - Terada, Seishi
AU - Sato, Shuhei
AU - Yoshida, Hidenori
AU - Honda, Hajime
AU - Takeda, Naoya
AU - Oshima, Etsuko
AU - Ishihara, Takeshi
AU - Kuroda, Shigetoshi
N1 - Funding Information:
We sincerely thank Ms. Ido, Ms. Horiuchi, Ms. Imai, and Ms. Yabe for their skillful assistance. This work was supported by grants from the Japanese Ministry of Education, Culture, Sports, Science and Technology , and the Zikei Institute of Psychiatry .
PY - 2010/12/30
Y1 - 2010/12/30
N2 - Repetitive questioning is among the most common and burdensome of the behavioral and psychological symptoms of Alzheimer's disease (AD). Regardless of the clinical significance of the repetitive questioning, the neural substrates involved remain unclear. Fifty-eight consecutive patients with AD participated in this study. The score of repetitive questioning behavior was evaluated by multiplying the severity by the frequency of the behavior. They underwent brain SPECT with 99mTc-ethylcysteinate dimer. Scores of repetitive questioning behavior had a significant positive correlation with regional cerebral blood flow (rCBF) in the bilateral pericallosal regions. After removing the effect of memory test scores, we found a significant positive correlation of scores of repetitive questioning behavior to rCBF in the left pericallosal region. The pericallosal region includes the upper precuneus, cingulate, and posterior cingulate cortices on 3DSRT. Repetitive questioning behavior among AD patients might be a manifestation of mental state associated with a relative increase or preservation of rCBF in the left pericallosal region.
AB - Repetitive questioning is among the most common and burdensome of the behavioral and psychological symptoms of Alzheimer's disease (AD). Regardless of the clinical significance of the repetitive questioning, the neural substrates involved remain unclear. Fifty-eight consecutive patients with AD participated in this study. The score of repetitive questioning behavior was evaluated by multiplying the severity by the frequency of the behavior. They underwent brain SPECT with 99mTc-ethylcysteinate dimer. Scores of repetitive questioning behavior had a significant positive correlation with regional cerebral blood flow (rCBF) in the bilateral pericallosal regions. After removing the effect of memory test scores, we found a significant positive correlation of scores of repetitive questioning behavior to rCBF in the left pericallosal region. The pericallosal region includes the upper precuneus, cingulate, and posterior cingulate cortices on 3DSRT. Repetitive questioning behavior among AD patients might be a manifestation of mental state associated with a relative increase or preservation of rCBF in the left pericallosal region.
KW - Alzheimer's disease
KW - Cingulate
KW - Precuneus
KW - Regional cerebral blood flow
KW - Single photon emission computed tomography
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U2 - 10.1016/j.pscychresns.2010.06.002
DO - 10.1016/j.pscychresns.2010.06.002
M3 - Article
C2 - 20971619
AN - SCOPUS:78449254827
SN - 0925-4927
VL - 184
SP - 151
EP - 156
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -
