TY - JOUR
T1 - Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats
AU - Takahashi, Mika
AU - Yabe, Kaoru
AU - Kato, Hina
AU - Kawamura, Tomoko
AU - Matsumoto, Mariko
AU - Hirata-Koizumi, Mutsuko
AU - Ono, Atsushi
AU - Hirose, Akihiko
N1 - Funding Information:
This study was supported by the Ministry of Health, Labour and Welfare, Japan .
PY - 2013/1
Y1 - 2013/1
N2 - Crl:CD(SD)rats were given 3-cyanopyridine by gavage at 0, 5, 30 or 180. mg/kg/day. Males were dosed for 42 days beginning 14 days before mating, and females for 40-53 days beginning 14 days before mating to day 3 of lactation, including throughout the mating and gestation periods. General toxicity, mainly liver damage, was observed in males at ≥30. mg/kg/day and in females at ≥5. mg/kg/day. Sertoli cell vacuolation was observed at 180. mg/kg/day, and spermatocyte damages were observed at ≥30. mg/kg/day. Effects on estrous cycles, corpora lutea and implantations, and unsuccessfully mated females, despite additional mating, were observed at 180. mg/kg/day. Delayed initiation of delivery, dystocia, and deaths or moribundities of pregnant females were observed at 180. mg/kg/day, and only two pregnant rats delivered live pups at that dose. The NOAEL for reproductive/developmental toxicity was concluded to be 30 mg/kg/day.
AB - Crl:CD(SD)rats were given 3-cyanopyridine by gavage at 0, 5, 30 or 180. mg/kg/day. Males were dosed for 42 days beginning 14 days before mating, and females for 40-53 days beginning 14 days before mating to day 3 of lactation, including throughout the mating and gestation periods. General toxicity, mainly liver damage, was observed in males at ≥30. mg/kg/day and in females at ≥5. mg/kg/day. Sertoli cell vacuolation was observed at 180. mg/kg/day, and spermatocyte damages were observed at ≥30. mg/kg/day. Effects on estrous cycles, corpora lutea and implantations, and unsuccessfully mated females, despite additional mating, were observed at 180. mg/kg/day. Delayed initiation of delivery, dystocia, and deaths or moribundities of pregnant females were observed at 180. mg/kg/day, and only two pregnant rats delivered live pups at that dose. The NOAEL for reproductive/developmental toxicity was concluded to be 30 mg/kg/day.
KW - 3-Cyanopyridine
KW - Rat
KW - Reproductive and developmental toxicity
KW - Testicular toxicity
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U2 - 10.1016/j.reprotox.2012.10.014
DO - 10.1016/j.reprotox.2012.10.014
M3 - Article
C2 - 23164985
AN - SCOPUS:84875234146
SN - 0890-6238
VL - 35
SP - 7
EP - 16
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 1
ER -