Retinoid X receptor antagonists

Masaki Watanabe; Hiroki Kakuta

doi:10.3390/ijms19082354

Retinoid X receptor antagonists

Masaki Watanabe, Hiroki Kakuta

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

Abstract

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

Original language	English
Article number	2354
Journal	International journal of molecular sciences
Volume	19
Issue number	8
DOIs	https://doi.org/10.3390/ijms19082354
Publication status	Published - Aug 10 2018

Keywords

Antagonists
Heterodimers
Ligands
Modulators
Non-permissive
Permissive
RXR
Retinoid X receptor
Structural classification
TRXR

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms19082354

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title = "Retinoid X receptor antagonists",

abstract = "Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.",

keywords = "Antagonists, Heterodimers, Ligands, Modulators, Non-permissive, Permissive, RXR, Retinoid X receptor, Structural classification, TRXR",

author = "Masaki Watanabe and Hiroki Kakuta",

note = "Funding Information: Funding: This paper was supported by Okayama University. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

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doi = "10.3390/ijms19082354",

language = "English",

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AU - Kakuta, Hiroki

PY - 2018/8/10

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AB - Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

KW - Antagonists

KW - Heterodimers

KW - Ligands

KW - Modulators

KW - Non-permissive

KW - Permissive

KW - RXR

KW - Retinoid X receptor

KW - Structural classification

KW - TRXR

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DO - 10.3390/ijms19082354

M3 - Review article

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SN - 1661-6596

VL - 19

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 8

M1 - 2354

ER -

Retinoid X receptor antagonists

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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