Retinoid X receptor antagonists

Masaki Watanabe, Hiroki Kakuta

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

Original languageEnglish
Article number2354
JournalInternational journal of molecular sciences
Issue number8
Publication statusPublished - Aug 10 2018


  • Antagonists
  • Heterodimers
  • Ligands
  • Modulators
  • Non-permissive
  • Permissive
  • RXR
  • Retinoid X receptor
  • Structural classification
  • TRXR

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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