Retrospective study of induction chemotherapy and concurrent chemoradiation therapy for oropharyngeal cancer

Takahiro Asakage, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Go Omura, Tatsuya Yamasoba

Research output: Contribution to journalArticlepeer-review


We carried out this study to clarify the treatment outcomes and problems associated with induction chemotherapy (using taxotere, cisplatin and 5-FU [TPF therapy]) and chemoradiotherapy in patients with oropharyngeal cancer. The data of 44 patients receiving their initial treatment for oropharyngeal cancer (including 2, 9 and 33 patients with stage II, stage III and stage IV disease, respectively, and 31, 8 and 3 patients with side wall, front wall and upper wall (soft palate and uvula) involvement) were examined. Of the 44 patients, 33 received induction chemotherapy and 11 received chemoradiotherapy. The feasibility, incidence of neutropenia, response rate, and 3 year disease-specific survival rate in the induction chemotherapy group vs. chemoradiotherapy group were 70%, 88%, 82% and 73%, respectively, vs. 63%, 91%, 82% and 55%, respectively. A statistically significant difference in the 3-year disease-specific survival rate was seen between the p16-positive and p16-negative patients in the induction chemotherapy group: while the rate was 100% in the p16-positive patients, it was only 51% in the p16-negative patients (p = 0.004). Of the patients undergoing chemoradio-therapy, 3 developed mandibular osteomyelitis, which was considered as one of the important problems associated with this therapy.

Original languageEnglish
Pages (from-to)1226-1232
Number of pages7
JournalJournal of Otolaryngology of Japan
Issue number10
Publication statusPublished - Oct 2015
Externally publishedYes


  • Human papilloma virus
  • Induction chemotherapy
  • Oropharyngeal cancer
  • P16

ASJC Scopus subject areas

  • Otorhinolaryngology


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