Riccardin C derivatives as anti-MRSA agents: Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s

Hiromi Sawada; Miki Okazaki; Daichi Morita; Teruo Kuroda; Kenji Matsuno; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1016/j.bmcl.2012.10.052

Riccardin C derivatives as anti-MRSA agents: Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s

Hiromi Sawada, Miki Okazaki, Daichi Morita, Teruo Kuroda, Kenji Matsuno, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated.

Original language	English
Pages (from-to)	7444-7447
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2012.10.052
Publication status	Published - Dec 15 2012
Externally published	Yes

Keywords

Anti-MRSA
Bis(bibenzyl)
Riccardin
SAR

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2012.10.052

Cite this

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title = "Riccardin C derivatives as anti-MRSA agents: Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s",

abstract = "Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated.",

keywords = "Anti-MRSA, Bis(bibenzyl), Riccardin, SAR",

author = "Hiromi Sawada and Miki Okazaki and Daichi Morita and Teruo Kuroda and Kenji Matsuno and Yuichi Hashimoto and Hiroyuki Miyachi",

note = "Funding Information: This work was supported in part by the Drug Discovery for Intractable Infectious Diseases Project, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, the Uehara Memorial Foundation, the Tokyo Biochemical Research Foundation (TBRF), and the Okayama Foundation for Science and Technology (OFST). ",

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doi = "10.1016/j.bmcl.2012.10.052",

language = "English",

volume = "22",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Riccardin C derivatives as anti-MRSA agents

T2 - Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s

AU - Sawada, Hiromi

AU - Okazaki, Miki

AU - Morita, Daichi

AU - Kuroda, Teruo

AU - Matsuno, Kenji

AU - Hashimoto, Yuichi

AU - Miyachi, Hiroyuki

N1 - Funding Information: This work was supported in part by the Drug Discovery for Intractable Infectious Diseases Project, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, the Uehara Memorial Foundation, the Tokyo Biochemical Research Foundation (TBRF), and the Okayama Foundation for Science and Technology (OFST).

PY - 2012/12/15

Y1 - 2012/12/15

N2 - Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated.

AB - Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated.

KW - Anti-MRSA

KW - Bis(bibenzyl)

KW - Riccardin

KW - SAR

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Riccardin C derivatives as anti-MRSA agents: Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s

Abstract

Keywords

ASJC Scopus subject areas

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