TY - JOUR
T1 - Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging
T2 - Radiological-pathological correlation
AU - Fujiwara, Hiroyasu
AU - Sekine, Shigeki
AU - Onaya, Hiroaki
AU - Shimada, Kazuaki
AU - Mikata, Rintaro
AU - Arai, Yasuaki
N1 - Funding Information:
Acknowledgments. We express our sincere thanks to Hidenori Ojima for valuable advice. This work was supported in part by grants-in-aid for Research on Publicly Essential Drugs and Medical Devices from the Japan Health Science Foundation and for Cancer Research (21S-1) from the Ministry of Health, Labor, and Welfare, Japan.
PY - 2011/12
Y1 - 2011/12
N2 - We report a case of focal nodular hyperplasia in a patient for whom gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)- enhanced magnetic resonance imaging (MRI) and histological analysis results were available. Dynamic contrast-enhanced computed tomography showed a well-defi ned hypervascular lesion 14 mm in diameter with no visible central scars. Gd-EOB-DTPA-enhanced MRI demonstrated strong peripheral enhancement of the lesion during the hepatobiliary phase, resulting in ring-like enhancement. The pathology examination revealed that the lesion was focal nodular hyperplasia (FNH). Immunohistochemistry showed positive expression of OATP8 in the hepatocytes in the peripheral areas of the lesion, whereas expression of OATP8 was lacking in hepatocytes surrounding the central radiating scar. Ring-like enhancement during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may be an important clue for the diagnosis of small FNH.
AB - We report a case of focal nodular hyperplasia in a patient for whom gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)- enhanced magnetic resonance imaging (MRI) and histological analysis results were available. Dynamic contrast-enhanced computed tomography showed a well-defi ned hypervascular lesion 14 mm in diameter with no visible central scars. Gd-EOB-DTPA-enhanced MRI demonstrated strong peripheral enhancement of the lesion during the hepatobiliary phase, resulting in ring-like enhancement. The pathology examination revealed that the lesion was focal nodular hyperplasia (FNH). Immunohistochemistry showed positive expression of OATP8 in the hepatocytes in the peripheral areas of the lesion, whereas expression of OATP8 was lacking in hepatocytes surrounding the central radiating scar. Ring-like enhancement during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may be an important clue for the diagnosis of small FNH.
KW - Focal nodular hyperplasia
KW - Gd-EOB-DTPA
KW - MRI
KW - Organic anion transporter
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U2 - 10.1007/s11604-011-0624-4
DO - 10.1007/s11604-011-0624-4
M3 - Article
C2 - 22009428
AN - SCOPUS:84856500812
SN - 1867-1071
VL - 29
SP - 739
EP - 743
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
IS - 10
ER -