Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer

Taka Eguchi; Thomas Prince; Barbara Wegiel; Stuart K. Calderwood

doi:10.1002/jcb.25203

Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer

Taka Eguchi, Thomas Prince, Barbara Wegiel, Stuart K. Calderwood

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors.

Original language	English
Pages (from-to)	2146-2154
Number of pages	9
Journal	Journal of Cellular Biochemistry
Volume	116
Issue number	10
DOIs	https://doi.org/10.1002/jcb.25203
Publication status	Published - Oct 1 2015
Externally published	Yes

Keywords

CANCER
FINGER-1
INVASION
MYELOID
NUCLEAR BODY
SUMO
ZINC

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jcb.25203

Cite this

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abstract = "Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors.",

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AU - Prince, Thomas

AU - Wegiel, Barbara

AU - Calderwood, Stuart K.

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KW - FINGER-1

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KW - NUCLEAR BODY

KW - SUMO

KW - ZINC

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Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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