Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis

Andrew M. LaFleur; Nicholas W. Lukacs; Steven L. Kunkel; Akihiro Matsukawa

doi:10.1080/09629350400014172

Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis

Andrew M. LaFleur, Nicholas W. Lukacs, Steven L. Kunkel, Akihiro Matsukawa

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CGL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.

Original language	English
Pages (from-to)	349-355
Number of pages	7
Journal	Mediators of Inflammation
Volume	13
Issue number	5-6
DOIs	https://doi.org/10.1080/09629350400014172
Publication status	Published - Dec 2004
Externally published	Yes

Keywords

Acute inflammation
CC chemokines
Eosinophils
Monocytes/macrophages
Neutrophils

ASJC Scopus subject areas

Immunology
Cell Biology

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10.1080/09629350400014172

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title = "Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis",

abstract = "THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CGL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.",

keywords = "Acute inflammation, CC chemokines, Eosinophils, Monocytes/macrophages, Neutrophils",

author = "LaFleur, {Andrew M.} and Lukacs, {Nicholas W.} and Kunkel, {Steven L.} and Akihiro Matsukawa",

year = "2004",

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AU - LaFleur, Andrew M.

AU - Lukacs, Nicholas W.

AU - Kunkel, Steven L.

AU - Matsukawa, Akihiro

PY - 2004/12

Y1 - 2004/12

N2 - THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CGL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.

AB - THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CGL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.

KW - Acute inflammation

KW - CC chemokines

KW - Eosinophils

KW - Monocytes/macrophages

KW - Neutrophils

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Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis

Abstract

Keywords

ASJC Scopus subject areas

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