Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma

Kyoichi Obata; Tsuyoshi Shimo; Tatsuo Okui; Kenichi Matsumoto; Hiroyuki Takada; Kiyofumi Takabatake; Yuki Kunisada; Soichiro Ibaragi; Norie Yoshioka; Koji Kishimoto; Hitoshi Nagatsuka; Akira Sasaki

doi:10.21873/anticanres.12060

Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma

Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Norie Yoshioka, Koji Kishimoto, Hitoshi Nagatsuka, Akira Sasaki

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

Original language	English
Pages (from-to)	6119-6123
Number of pages	5
Journal	Anticancer research
Volume	37
Issue number	11
DOIs	https://doi.org/10.21873/anticanres.12060
Publication status	Published - Nov 2017

Keywords

Neurokinin 3 Receptor
Neurokinin B
Oral squamous cell carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.12060

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title = "Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma",

abstract = "Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.",

keywords = "Neurokinin 3 Receptor, Neurokinin B, Oral squamous cell carcinoma",

author = "Kyoichi Obata and Tsuyoshi Shimo and Tatsuo Okui and Kenichi Matsumoto and Hiroyuki Takada and Kiyofumi Takabatake and Yuki Kunisada and Soichiro Ibaragi and Norie Yoshioka and Koji Kishimoto and Hitoshi Nagatsuka and Akira Sasaki",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (B) (#JP26293428 to T.S.) from the Japan Society for the Promotion of Sciences.",

year = "2017",

month = nov,

doi = "10.21873/anticanres.12060",

language = "English",

volume = "37",

pages = "6119--6123",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma

AU - Obata, Kyoichi

AU - Shimo, Tsuyoshi

AU - Okui, Tatsuo

AU - Matsumoto, Kenichi

AU - Takada, Hiroyuki

AU - Takabatake, Kiyofumi

AU - Kunisada, Yuki

AU - Ibaragi, Soichiro

AU - Yoshioka, Norie

AU - Kishimoto, Koji

AU - Nagatsuka, Hitoshi

AU - Sasaki, Akira

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (B) (#JP26293428 to T.S.) from the Japan Society for the Promotion of Sciences.

PY - 2017/11

Y1 - 2017/11

N2 - Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

AB - Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

KW - Neurokinin 3 Receptor

KW - Neurokinin B

KW - Oral squamous cell carcinoma

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Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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