Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Toshiaki Sendo; Yoshinori Itoh; Takeshi Goromaru; Toshio Hirakawa; Mawako Ishida; Hitoo Nakano; Ryozo Oishi

doi:10.1016/j.peptides.2004.04.004

Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Toshiaki Sendo, Yoshinori Itoh, Takeshi Goromaru, Toshio Hirakawa, Mawako Ishida, Hitoo Nakano, Ryozo Oishi

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook post-operative chemotherapy for ovarian cancer. In rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK₁ antagonist LY303870. Substance P level in rat plasma and bronchoalveolar lavage fluid increased after paclitaxel injection. In 13 patients, plasma level of substance P but not histamine significantly (P<0.05) increased during paclitaxel infusion. Therefore, substance P rather than histamine may be involved in paclitaxel hypersensitivity.

Original language	English
Pages (from-to)	1205-1208
Number of pages	4
Journal	Peptides
Volume	25
Issue number	7
DOIs	https://doi.org/10.1016/j.peptides.2004.04.004
Publication status	Published - Jul 2004
Externally published	Yes

Keywords

Acute lung injury
Histamine
Hypersensitivity
NK antagonist
Paclitaxel
Plasma extravasation
Substance P

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.peptides.2004.04.004

Cite this

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title = "Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent",

abstract = "The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook post-operative chemotherapy for ovarian cancer. In rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK1 antagonist LY303870. Substance P level in rat plasma and bronchoalveolar lavage fluid increased after paclitaxel injection. In 13 patients, plasma level of substance P but not histamine significantly (P<0.05) increased during paclitaxel infusion. Therefore, substance P rather than histamine may be involved in paclitaxel hypersensitivity.",

keywords = "Acute lung injury, Histamine, Hypersensitivity, NK antagonist, Paclitaxel, Plasma extravasation, Substance P",

author = "Toshiaki Sendo and Yoshinori Itoh and Takeshi Goromaru and Toshio Hirakawa and Mawako Ishida and Hitoo Nakano and Ryozo Oishi",

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T1 - Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

AU - Sendo, Toshiaki

AU - Itoh, Yoshinori

AU - Goromaru, Takeshi

AU - Hirakawa, Toshio

AU - Ishida, Mawako

AU - Nakano, Hitoo

AU - Oishi, Ryozo

PY - 2004/7

Y1 - 2004/7

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AB - The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook post-operative chemotherapy for ovarian cancer. In rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK1 antagonist LY303870. Substance P level in rat plasma and bronchoalveolar lavage fluid increased after paclitaxel injection. In 13 patients, plasma level of substance P but not histamine significantly (P<0.05) increased during paclitaxel infusion. Therefore, substance P rather than histamine may be involved in paclitaxel hypersensitivity.

KW - Acute lung injury

KW - Histamine

KW - Hypersensitivity

KW - NK antagonist

KW - Paclitaxel

KW - Plasma extravasation

KW - Substance P

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ER -

Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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