Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation

Nobuaki Miyahara; Satoko Miyahara; Katsuyuki Takeda; Erwin W. Gelfand

doi:10.2332/allergolint.55.91

Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation

Nobuaki Miyahara, Satoko Miyahara, Katsuyuki Takeda, Erwin W. Gelfand

Research output: Contribution to journal › Review article › peer-review

52 Citations (Scopus)

Abstract

LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory disorders. BLT1, a G-protein-coupled receptor, has recently been identified as a high affinity receptor specific for LTB4. Recent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions. The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.

Original language	English
Pages (from-to)	91-97
Number of pages	7
Journal	Allergology International
Volume	55
Issue number	2
DOIs	https://doi.org/10.2332/allergolint.55.91
Publication status	Published - Jun 2006
Externally published	Yes

Keywords

Airway responsiveness
Cytokines
Lipid mediators
Lung inflammation
T cells

ASJC Scopus subject areas

Immunology and Allergy

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10.2332/allergolint.55.91

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title = "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation",

abstract = "LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory disorders. BLT1, a G-protein-coupled receptor, has recently been identified as a high affinity receptor specific for LTB4. Recent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions. The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.",

keywords = "Airway responsiveness, Cytokines, Lipid mediators, Lung inflammation, T cells",

author = "Nobuaki Miyahara and Satoko Miyahara and Katsuyuki Takeda and Gelfand, {Erwin W.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (HL-36577 and HL-61005). We are indebted to Drs. Andrew Tager, Andrew Luster, and Haribabu Bodduluri for providing deficient mice which were essential to our investigations.",

year = "2006",

month = jun,

doi = "10.2332/allergolint.55.91",

language = "English",

volume = "55",

pages = "91--97",

journal = "Allergology International",

issn = "1323-8930",

publisher = "Japanese Society of Allergology",

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AU - Miyahara, Nobuaki

AU - Miyahara, Satoko

AU - Takeda, Katsuyuki

AU - Gelfand, Erwin W.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (HL-36577 and HL-61005). We are indebted to Drs. Andrew Tager, Andrew Luster, and Haribabu Bodduluri for providing deficient mice which were essential to our investigations.

PY - 2006/6

Y1 - 2006/6

N2 - LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory disorders. BLT1, a G-protein-coupled receptor, has recently been identified as a high affinity receptor specific for LTB4. Recent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions. The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.

AB - LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory disorders. BLT1, a G-protein-coupled receptor, has recently been identified as a high affinity receptor specific for LTB4. Recent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions. The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.

KW - Airway responsiveness

KW - Cytokines

KW - Lipid mediators

KW - Lung inflammation

KW - T cells

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DO - 10.2332/allergolint.55.91

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SN - 1323-8930

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JO - Allergology International

JF - Allergology International

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Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation

Abstract

Keywords

ASJC Scopus subject areas

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