Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion

Yumiko Momose; Tomoyuki Honda; Maiko Inagaki; Kazuya Shimizu; Kenji Irie; Hiroyuki Nakanishi; Yoshimi Takai

doi:10.1016/S0006-291X(02)00183-3

Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion

Yumiko Momose, Tomoyuki Honda, Maiko Inagaki, Kazuya Shimizu, Kenji Irie, Hiroyuki Nakanishi, Yoshimi Takai

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Nectin is a Ca²⁺-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	293
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(02)00183-3
Publication status	Published - 2002
Externally published	Yes

Keywords

Adherens junctions
Cell-cell adhesion
cis-Dimers
Ig-like cell adhesion molecule
Nectin
trans-Dimers

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(02)00183-3

Cite this

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title = "Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion",

abstract = "Nectin is a Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation.",

keywords = "Adherens junctions, Cell-cell adhesion, cis-Dimers, Ig-like cell adhesion molecule, Nectin, trans-Dimers",

author = "Yumiko Momose and Tomoyuki Honda and Maiko Inagaki and Kazuya Shimizu and Kenji Irie and Hiroyuki Nakanishi and Yoshimi Takai",

note = "Funding Information: The investigation was supported by grants-in-aid for Scientific Research and for Cancer Research from Ministry of Education, Culture, Sports, Science, and Technology, Japan (2001, 2002).",

year = "2002",

doi = "10.1016/S0006-291X(02)00183-3",

language = "English",

volume = "293",

pages = "45--49",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

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T1 - Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion

AU - Momose, Yumiko

AU - Honda, Tomoyuki

AU - Inagaki, Maiko

AU - Shimizu, Kazuya

AU - Irie, Kenji

AU - Nakanishi, Hiroyuki

AU - Takai, Yoshimi

N1 - Funding Information: The investigation was supported by grants-in-aid for Scientific Research and for Cancer Research from Ministry of Education, Culture, Sports, Science, and Technology, Japan (2001, 2002).

PY - 2002

Y1 - 2002

N2 - Nectin is a Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation.

AB - Nectin is a Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation.

KW - Adherens junctions

KW - Cell-cell adhesion

KW - cis-Dimers

KW - Ig-like cell adhesion molecule

KW - Nectin

KW - trans-Dimers

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AN - SCOPUS:0036293996

SN - 0006-291X

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion

Abstract

Keywords

ASJC Scopus subject areas

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