Role of the TRPM4 channel in cardiovascular physiology and pathophysiology

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32 Citations (Scopus)


The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology.

Original languageEnglish
Article number62
Issue number6
Publication statusPublished - Jun 15 2018


  • Cardiovascular system
  • Pathophysiology
  • Physiology
  • TRPM4 channel

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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