Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

Yasushi Nishihara; Yoshiaki Inoue; Mamoru Fujisawa; Kentaro Takagi

doi:10.1055/s-2005-872661

Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

Yasushi Nishihara, Yoshiaki Inoue, Mamoru Fujisawa, Kentaro Takagi

Research Institute for Interdisciplinary Science

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

Original language	English
Pages (from-to)	2309-2312
Number of pages	4
Journal	Synlett
Issue number	15
DOIs	https://doi.org/10.1055/s-2005-872661
Publication status	Published - Sept 19 2005

Keywords

Boronic acid
Copper
Cross-coupling reaction
Ketones
Palladium

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-2005-872661

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abstract = "The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.",

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author = "Yasushi Nishihara and Yoshiaki Inoue and Mamoru Fujisawa and Kentaro Takagi",

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doi = "10.1055/s-2005-872661",

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T1 - Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

AU - Nishihara, Yasushi

AU - Inoue, Yoshiaki

AU - Fujisawa, Mamoru

AU - Takagi, Kentaro

PY - 2005/9/19

Y1 - 2005/9/19

N2 - The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

AB - The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

KW - Boronic acid

KW - Copper

KW - Cross-coupling reaction

KW - Ketones

KW - Palladium

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JF - Synlett

IS - 15

ER -

Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

Abstract

Keywords

ASJC Scopus subject areas

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