S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis

Masakiyo Sakaguchi

doi:10.7150/thno.19866

S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis

Masakiyo Sakaguchi

Research output: Contribution to journal › Editorial › peer-review

6 Citations (Scopus)

Abstract

Great progress has been made in in vivo imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed tomography (SPECT) probe for imaging and succeeded in detecting the metastatic organ favored by the cancer before the cancer arrival. By utilizing this advanced method, researchers have also found that cancer-derived monocytes are the main source of the abundant production of S100A8/A9 in the pre-metastatic area. The CCL2-CCR2 axis is associated with S100A8/A9 production. Clinical establishment of this technique is expected to enable accurate prediction and monitoring of cancer metastasis during therapy.

Original language	English
Pages (from-to)	2649-2651
Number of pages	3
Journal	Theranostics
Volume	7
Issue number	10
DOIs	https://doi.org/10.7150/thno.19866
Publication status	Published - 2017

Keywords

CCL2
CCR2
In vivo imaging
Inflammation
Monocytes
Organ-specific metastasis
Pre-metastatic niche
S100A8/A9

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7150/thno.19866

Cite this

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title = "S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis",

abstract = "Great progress has been made in in vivo imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed tomography (SPECT) probe for imaging and succeeded in detecting the metastatic organ favored by the cancer before the cancer arrival. By utilizing this advanced method, researchers have also found that cancer-derived monocytes are the main source of the abundant production of S100A8/A9 in the pre-metastatic area. The CCL2-CCR2 axis is associated with S100A8/A9 production. Clinical establishment of this technique is expected to enable accurate prediction and monitoring of cancer metastasis during therapy.",

keywords = "CCL2, CCR2, In vivo imaging, Inflammation, Monocytes, Organ-specific metastasis, Pre-metastatic niche, S100A8/A9",

author = "Masakiyo Sakaguchi",

note = "Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2017",

doi = "10.7150/thno.19866",

language = "English",

volume = "7",

pages = "2649--2651",

journal = "Theranostics",

issn = "1838-7640",

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TY - JOUR

T1 - S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis

AU - Sakaguchi, Masakiyo

N1 - Publisher Copyright: © Ivyspring International Publisher.

PY - 2017

Y1 - 2017

N2 - Great progress has been made in in vivo imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed tomography (SPECT) probe for imaging and succeeded in detecting the metastatic organ favored by the cancer before the cancer arrival. By utilizing this advanced method, researchers have also found that cancer-derived monocytes are the main source of the abundant production of S100A8/A9 in the pre-metastatic area. The CCL2-CCR2 axis is associated with S100A8/A9 production. Clinical establishment of this technique is expected to enable accurate prediction and monitoring of cancer metastasis during therapy.

AB - Great progress has been made in in vivo imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed tomography (SPECT) probe for imaging and succeeded in detecting the metastatic organ favored by the cancer before the cancer arrival. By utilizing this advanced method, researchers have also found that cancer-derived monocytes are the main source of the abundant production of S100A8/A9 in the pre-metastatic area. The CCL2-CCR2 axis is associated with S100A8/A9 production. Clinical establishment of this technique is expected to enable accurate prediction and monitoring of cancer metastasis during therapy.

KW - CCL2

KW - CCR2

KW - In vivo imaging

KW - Inflammation

KW - Monocytes

KW - Organ-specific metastasis

KW - Pre-metastatic niche

KW - S100A8/A9

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U2 - 10.7150/thno.19866

DO - 10.7150/thno.19866

M3 - Editorial

C2 - 28819453

AN - SCOPUS:85021222914

SN - 1838-7640

VL - 7

SP - 2649

EP - 2651

JO - Theranostics

JF - Theranostics

IS - 10

ER -

S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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