S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Jyoti K. Jaiswal; Stine P. Lauritzen; Luana Scheffer; Masakiyo Sakaguchi; Jakob Bunkenborg; Sanford M. Simon; Tuula Kallunki; Marja Jäättelä; Jesper Nylandsted

doi:10.1038/ncomms4795

S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Jyoti K. Jaiswal, Stine P. Lauritzen, Luana Scheffer, Masakiyo Sakaguchi, Jakob Bunkenborg, Sanford M. Simon, Tuula Kallunki, Marja Jäättelä, Jesper Nylandsted

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Abstract

Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S100A11, a calcium-binding protein upregulated in a variety of metastatic cancers, is essential for efficient plasma membrane repair and survival of highly motile cancer cells. Plasma membrane injury-induced entry of calcium into the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury. We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and excision of the damaged part of the plasma membrane. These data reveal plasma membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy of metastatic cancers.

Original language	English
Article number	3795
Journal	Nature communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms4795
Publication status	Published - May 8 2014

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells",

abstract = "Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S100A11, a calcium-binding protein upregulated in a variety of metastatic cancers, is essential for efficient plasma membrane repair and survival of highly motile cancer cells. Plasma membrane injury-induced entry of calcium into the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury. We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and excision of the damaged part of the plasma membrane. These data reveal plasma membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy of metastatic cancers.",

author = "Jaiswal, {Jyoti K.} and Lauritzen, {Stine P.} and Luana Scheffer and Masakiyo Sakaguchi and Jakob Bunkenborg and Simon, {Sanford M.} and Tuula Kallunki and Marja J{\"a}{\"a}ttel{\"a} and Jesper Nylandsted",

note = "Funding Information: We thank K. Gr{\o}n Henriksen for excellent technical assistance. We thank Drs Arun Deora and Kathy Hajjar (Weill Medical College of Cornell University, NY) for Annexin A2 constructs and Dr William Bement (University of Wisconsin-Madison) for Utrophin-mCherry construct. We thank all members of the Jaiswal lab and Unit for Cell Death and Metabolism for their helpful comments as well as assistance in carrying out this work. This work was supported by National Institutes of Health Grants R01AR055686, P50AR060836 and P30HD040677 (J.K.J.), Danish Medical Research Council (J.N. and M.J.), Danish Cancer Society (M.J.), Lundbeck Foundation (M.J.), Novo Nordisk Foundation (M.J.) and Association for International Cancer Research (M.J.).",

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AU - Jaiswal, Jyoti K.

AU - Lauritzen, Stine P.

AU - Scheffer, Luana

AU - Sakaguchi, Masakiyo

AU - Bunkenborg, Jakob

AU - Simon, Sanford M.

AU - Kallunki, Tuula

AU - Jäättelä, Marja

AU - Nylandsted, Jesper

N1 - Funding Information: We thank K. Grøn Henriksen for excellent technical assistance. We thank Drs Arun Deora and Kathy Hajjar (Weill Medical College of Cornell University, NY) for Annexin A2 constructs and Dr William Bement (University of Wisconsin-Madison) for Utrophin-mCherry construct. We thank all members of the Jaiswal lab and Unit for Cell Death and Metabolism for their helpful comments as well as assistance in carrying out this work. This work was supported by National Institutes of Health Grants R01AR055686, P50AR060836 and P30HD040677 (J.K.J.), Danish Medical Research Council (J.N. and M.J.), Danish Cancer Society (M.J.), Lundbeck Foundation (M.J.), Novo Nordisk Foundation (M.J.) and Association for International Cancer Research (M.J.).

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N2 - Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S100A11, a calcium-binding protein upregulated in a variety of metastatic cancers, is essential for efficient plasma membrane repair and survival of highly motile cancer cells. Plasma membrane injury-induced entry of calcium into the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury. We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and excision of the damaged part of the plasma membrane. These data reveal plasma membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy of metastatic cancers.

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S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

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