Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening

Takeki Uehara; Atsushi Ono; Toshiyuki Maruyama; Ikuo Kato; Hiroshi Yamada; Yasuo Ohno; Tetsuro Urushidani

doi:10.1002/9783527634705.ch3b

Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening

Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese toxicogenomics project.

Original language	English
Title of host publication	Risk Assessment of Phytochemicals in Food
Subtitle of host publication	Novel Approaches
Publisher	Wiley Blackwell
Pages	254-271
Number of pages	18
ISBN (Print)	9783527329298
DOIs	https://doi.org/10.1002/9783527634705.ch3b
Publication status	Published - Dec 15 2010
Externally published	Yes

Keywords

Carcinogen specific expression profiling
Genomics biomarkers
Profiling techniques
Safety testing
Toxicogenomics

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/9783527634705.ch3b

Fingerprint

Dive into the research topics of 'Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening'. Together they form a unique fingerprint.

Cite this

Uehara, T., Ono, A., Maruyama, T., Kato, I., Yamada, H., Ohno, Y., & Urushidani, T. (2010). Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening. In Risk Assessment of Phytochemicals in Food: Novel Approaches (pp. 254-271). Wiley Blackwell. https://doi.org/10.1002/9783527634705.ch3b

Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening. / Uehara, Takeki; Ono, Atsushi; Maruyama, Toshiyuki et al.
Risk Assessment of Phytochemicals in Food: Novel Approaches. Wiley Blackwell, 2010. p. 254-271.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Uehara, T, Ono, A, Maruyama, T, Kato, I, Yamada, H, Ohno, Y & Urushidani, T 2010, Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening. in Risk Assessment of Phytochemicals in Food: Novel Approaches. Wiley Blackwell, pp. 254-271. https://doi.org/10.1002/9783527634705.ch3b

Uehara T, Ono A, Maruyama T, Kato I, Yamada H, Ohno Y et al. Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening. In Risk Assessment of Phytochemicals in Food: Novel Approaches. Wiley Blackwell. 2010. p. 254-271 doi: 10.1002/9783527634705.ch3b

Uehara, Takeki ; Ono, Atsushi ; Maruyama, Toshiyuki et al. / Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements : Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening. Risk Assessment of Phytochemicals in Food: Novel Approaches. Wiley Blackwell, 2010. pp. 254-271

@inbook{3eb8a729fc7b4a76bb8257894c16f59a,

title = "Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening",

abstract = "Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese toxicogenomics project.",

keywords = "Carcinogen specific expression profiling, Genomics biomarkers, Profiling techniques, Safety testing, Toxicogenomics",

author = "Takeki Uehara and Atsushi Ono and Toshiyuki Maruyama and Ikuo Kato and Hiroshi Yamada and Yasuo Ohno and Tetsuro Urushidani",

year = "2010",

month = dec,

day = "15",

doi = "10.1002/9783527634705.ch3b",

language = "English",

isbn = "9783527329298",

pages = "254--271",

booktitle = "Risk Assessment of Phytochemicals in Food",

publisher = "Wiley Blackwell",

}

TY - CHAP

T1 - Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements

T2 - Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening

AU - Uehara, Takeki

AU - Ono, Atsushi

AU - Maruyama, Toshiyuki

AU - Kato, Ikuo

AU - Yamada, Hiroshi

AU - Ohno, Yasuo

AU - Urushidani, Tetsuro

PY - 2010/12/15

Y1 - 2010/12/15

N2 - Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese toxicogenomics project.

AB - Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese toxicogenomics project.

KW - Carcinogen specific expression profiling

KW - Genomics biomarkers

KW - Profiling techniques

KW - Safety testing

KW - Toxicogenomics

UR - http://www.scopus.com/inward/record.url?scp=84888745309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888745309&partnerID=8YFLogxK

U2 - 10.1002/9783527634705.ch3b

DO - 10.1002/9783527634705.ch3b

M3 - Chapter

AN - SCOPUS:84888745309

SN - 9783527329298

SP - 254

EP - 271

BT - Risk Assessment of Phytochemicals in Food

PB - Wiley Blackwell

ER -

Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this