Salivary stress biomarker levels during speech in patients with maxillectomy defect

Yukiko Ugawa, Goro Nishigawa, Yukinori Maruo, Michihiro Suwaki, Shogo Minagi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background After resection of maxillofacial tumors, severe functional problems related to mastication, deglutition, and speech are observed in addition to the changes in appearance and psychosocial functioning. Although speech outcome is recovered with prosthetic treatments, patients sometimes complain of continued dissatisfaction with their speech. The purpose of this study was to evaluate the potential dissatisfaction of patients with maxillectomy defects during speech. Methods Sixteen patients with maxillary obturator were compared with a matched control group. Functional improvement by the maxillofacial prosthesis was confirmed using a speech intelligibility test, a chewing function score, and visual analogue scale on subjective satisfaction. Cortisol and chromogranin A (CgA) were evaluated after prescribed speech tasks. Results CgA in patients with maxillectomy defects was significantly higher than that in the control group (p <.05), even after the functional improvement by maxillofacial prosthesis. Conclusion It was revealed that patients with maxillectomy defects have significant psychological stresses during speech, even when their maxillofacial prosthesis resulted in successful functional improvement.

Original languageEnglish
Pages (from-to)620-626
Number of pages7
JournalHead and Neck
Issue number5
Publication statusPublished - May 2011


  • maxillectomy
  • obturator
  • quality of life
  • speech
  • stress

ASJC Scopus subject areas

  • Otorhinolaryngology


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