SAPHO syndrome associated spondylitis

Tomoyuki Takigawa, Masato Tanaka, Kazuo Nakanishi, Haruo Misawa, Yoshihisa Sugimoto, Tomohiro Takahata, Hiroyuki Nakahara, Shinnosuke Nakahara, Toshifumi Ozaki

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.

Original languageEnglish
Pages (from-to)1391-1397
Number of pages7
JournalEuropean Spine Journal
Issue number10
Publication statusPublished - Oct 2008


  • Non-marginal syndesmophyte
  • Palmoplantar pustulosis
  • SAPHO syndrome
  • Seronegative spondyloarthropathy
  • Spondylitis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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