TY - JOUR
T1 - SAPHO syndrome associated spondylitis
AU - Takigawa, Tomoyuki
AU - Tanaka, Masato
AU - Nakanishi, Kazuo
AU - Misawa, Haruo
AU - Sugimoto, Yoshihisa
AU - Takahata, Tomohiro
AU - Nakahara, Hiroyuki
AU - Nakahara, Shinnosuke
AU - Ozaki, Toshifumi
PY - 2008/10
Y1 - 2008/10
N2 - The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.
AB - The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.
KW - Non-marginal syndesmophyte
KW - Palmoplantar pustulosis
KW - SAPHO syndrome
KW - Seronegative spondyloarthropathy
KW - Spondylitis
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UR - http://www.scopus.com/inward/citedby.url?scp=53149084080&partnerID=8YFLogxK
U2 - 10.1007/s00586-008-0722-x
DO - 10.1007/s00586-008-0722-x
M3 - Article
C2 - 18642032
AN - SCOPUS:53149084080
SN - 0940-6719
VL - 17
SP - 1391
EP - 1397
JO - European Spine Journal
JF - European Spine Journal
IS - 10
ER -