Sarcoidosis occurring after interferon-α therapy for chronic hepatitis C: Report of two cases

Atsushi Hirano; Mikio Kataoka; Yasunari Nakata; Katsuyuki Takeda; Takayuki Kamao; Junichi Hiramatsu; Goro Kimura; Yasushi Tanimoto; Arihiko Kanehiro; Mitsune Tanimoto

doi:10.1111/j.1440-1843.2005.00745.x

Sarcoidosis occurring after interferon-α therapy for chronic hepatitis C: Report of two cases

Atsushi Hirano, Mikio Kataoka, Yasunari Nakata, Katsuyuki Takeda, Takayuki Kamao, Junichi Hiramatsu, Goro Kimura, Yasushi Tanimoto, Arihiko Kanehiro, Mitsune Tanimoto

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We report two patients who were diagnosed with sarcoidosis after receiving interferon (IFN)-α therapy for chronic hepatitis C, and conduct a review the relevant literature. The first patient was a 52-year-old female who developed multiple subcutaneous nodules 2 months after finishing IFN-α therapy. A skin biopsy from subcutaneous nodules on the right elbow joint revealed sarcoid granulomata. These lesions resolved spontaneously 4 months later. The second patient, a 57-year-old male, developed bilateral hilar and mediastinal lymph node enlargement 2 years after finishing IFN-α 2a therapy. A transbronchial lung biopsy demonstrated sarcoid granulomata. In addition, he had uveitis and left ulnar nerve involvement. His eye and nerve involvement gradually improved over 20 months. It is feasible that IFN therapy has been a trigger for sarcoidosis in these patients.

Original language	English
Pages (from-to)	529-534
Number of pages	6
Journal	Respirology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1843.2005.00745.x
Publication status	Published - Sept 2005

Keywords

Chronic hepatitis C
Granuloma
Interferon-α
Sarcoidosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1440-1843.2005.00745.x

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title = "Sarcoidosis occurring after interferon-α therapy for chronic hepatitis C: Report of two cases",

abstract = "We report two patients who were diagnosed with sarcoidosis after receiving interferon (IFN)-α therapy for chronic hepatitis C, and conduct a review the relevant literature. The first patient was a 52-year-old female who developed multiple subcutaneous nodules 2 months after finishing IFN-α therapy. A skin biopsy from subcutaneous nodules on the right elbow joint revealed sarcoid granulomata. These lesions resolved spontaneously 4 months later. The second patient, a 57-year-old male, developed bilateral hilar and mediastinal lymph node enlargement 2 years after finishing IFN-α 2a therapy. A transbronchial lung biopsy demonstrated sarcoid granulomata. In addition, he had uveitis and left ulnar nerve involvement. His eye and nerve involvement gradually improved over 20 months. It is feasible that IFN therapy has been a trigger for sarcoidosis in these patients.",

keywords = "Chronic hepatitis C, Granuloma, Interferon-α, Sarcoidosis",

author = "Atsushi Hirano and Mikio Kataoka and Yasunari Nakata and Katsuyuki Takeda and Takayuki Kamao and Junichi Hiramatsu and Goro Kimura and Yasushi Tanimoto and Arihiko Kanehiro and Mitsune Tanimoto",

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AU - Hirano, Atsushi

AU - Kataoka, Mikio

AU - Nakata, Yasunari

AU - Takeda, Katsuyuki

AU - Kamao, Takayuki

AU - Hiramatsu, Junichi

AU - Kimura, Goro

AU - Tanimoto, Yasushi

AU - Kanehiro, Arihiko

AU - Tanimoto, Mitsune

PY - 2005/9

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N2 - We report two patients who were diagnosed with sarcoidosis after receiving interferon (IFN)-α therapy for chronic hepatitis C, and conduct a review the relevant literature. The first patient was a 52-year-old female who developed multiple subcutaneous nodules 2 months after finishing IFN-α therapy. A skin biopsy from subcutaneous nodules on the right elbow joint revealed sarcoid granulomata. These lesions resolved spontaneously 4 months later. The second patient, a 57-year-old male, developed bilateral hilar and mediastinal lymph node enlargement 2 years after finishing IFN-α 2a therapy. A transbronchial lung biopsy demonstrated sarcoid granulomata. In addition, he had uveitis and left ulnar nerve involvement. His eye and nerve involvement gradually improved over 20 months. It is feasible that IFN therapy has been a trigger for sarcoidosis in these patients.

AB - We report two patients who were diagnosed with sarcoidosis after receiving interferon (IFN)-α therapy for chronic hepatitis C, and conduct a review the relevant literature. The first patient was a 52-year-old female who developed multiple subcutaneous nodules 2 months after finishing IFN-α therapy. A skin biopsy from subcutaneous nodules on the right elbow joint revealed sarcoid granulomata. These lesions resolved spontaneously 4 months later. The second patient, a 57-year-old male, developed bilateral hilar and mediastinal lymph node enlargement 2 years after finishing IFN-α 2a therapy. A transbronchial lung biopsy demonstrated sarcoid granulomata. In addition, he had uveitis and left ulnar nerve involvement. His eye and nerve involvement gradually improved over 20 months. It is feasible that IFN therapy has been a trigger for sarcoidosis in these patients.

KW - Chronic hepatitis C

KW - Granuloma

KW - Interferon-α

KW - Sarcoidosis

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Sarcoidosis occurring after interferon-α therapy for chronic hepatitis C: Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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