TY - JOUR
T1 - Scalp-recorded high-frequency oscillations in childhood sleep-induced electrical status epilepticus
AU - Kobayashi, Katsuhiro
AU - Watanabe, Yoshiaki
AU - Inoue, Takushi
AU - Oka, Makio
AU - Yoshinaga, Harumi
AU - Ohtsuka, Yoko
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Because high-frequency oscillations (HFOs) may affect normal brain functions, we examined them using electroencephalography (EEG) in epilepsy with continuous spike-waves during slow-wave sleep (CSWS), a condition that can cause neuropsychological regression. In 10 children between 6 and 9 years of age with epilepsy with CSWS or related disorders, we investigated HFOs in scalp EEG spikes during slow-wave sleep through temporal expansion of the EEG traces with a low-cut frequency filter at 70 Hz as well as through time-frequency power spectral analysis. HFOs (ripples) concurrent with spikes were detected in the temporally expanded traces, and the frequency of the high-frequency peak with the greatest power in each patient's spectra ranged from 97.7 to 140.6 Hz. This is the first report on the detection of HFOs from scalp EEG recordings in epileptic patients. We speculate that epileptic HFOs may interfere with higher brain functions in epilepsy with CSWS.
AB - Because high-frequency oscillations (HFOs) may affect normal brain functions, we examined them using electroencephalography (EEG) in epilepsy with continuous spike-waves during slow-wave sleep (CSWS), a condition that can cause neuropsychological regression. In 10 children between 6 and 9 years of age with epilepsy with CSWS or related disorders, we investigated HFOs in scalp EEG spikes during slow-wave sleep through temporal expansion of the EEG traces with a low-cut frequency filter at 70 Hz as well as through time-frequency power spectral analysis. HFOs (ripples) concurrent with spikes were detected in the temporally expanded traces, and the frequency of the high-frequency peak with the greatest power in each patient's spectra ranged from 97.7 to 140.6 Hz. This is the first report on the detection of HFOs from scalp EEG recordings in epileptic patients. We speculate that epileptic HFOs may interfere with higher brain functions in epilepsy with CSWS.
KW - Childhood
KW - Continuous spike-waves during slow-wave sleep
KW - EEG
KW - High-frequency oscillations
KW - Landau-Kleffner syndrome
KW - Time-frequency analysis
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U2 - 10.1111/j.1528-1167.2010.02565.x
DO - 10.1111/j.1528-1167.2010.02565.x
M3 - Article
C2 - 20384717
AN - SCOPUS:78649251216
SN - 0013-9580
VL - 51
SP - 2190
EP - 2194
JO - Epilepsia
JF - Epilepsia
IS - 10
ER -