TY - JOUR
T1 - Screening program of prostate cancer at Tokai University Hospital
T2 - Characterization of prostate-specific antigen measurement
AU - Tokunaga, Masatoshi
AU - Yasuda, Masanori
AU - Miyakita, Hideshi
AU - Kawamura, Yoshiaki
AU - Shoji, Sunao
AU - Sasaki, Hiroshi
AU - Kono, Takuo
AU - Kobayashi, Yasuyuki
AU - Shima, Masanori
AU - Usui, Yukio
AU - Masuda, Aiichiro
AU - Kinoshita, Hidechika
AU - Ogawa, Teppei
AU - Honma, Yasuhiko
AU - Osamura, R. Yoshiyuki
AU - Terachi, Toshiro
PY - 2005/7/1
Y1 - 2005/7/1
N2 - A total of 67,214 men participated in screening for prostate cancer (PC) using serum prostate-specific antigen (PSA) from April 1996 to March 2003 at Tokai University Hospital. In 3.5% (2,330/67,214) of the men, an elevated PSA level (>4.0 ng/ml) was found and 68.1% (1,586/2,330) of these subjects were examined at our Urological Outpatient Clinic. Re-testing of PSA showed that 8.4% (133/1,586) had a normal level. Needle biopsy of the prostate was performed in 45.2% (633/1,453) of the remaining men. As a result, 142 PCs were found and the detection rate was 0.2% (142/67,214). The age of the patients with PC was over 50 years. During this period, 135 individuals with voiding dysfunction were also diagnosed as having PC. Comparison of the patients detected by screening with those found at the outpatient clinic revealed significant differences of the age (64.8 vs. 71.9 years, p<0.0001), serum PSA level (14.6 vs. 154.9 ng/ml, p<0.0001), and clinical stage (p<0.0001). In conclusion, a health screening program that includes serum PSA testing is useful for detection of PC at an earlier stage and in younger individuals. We recommend that all men aged 50 years or older undergo testing for PSA to detect PC at an early stage.
AB - A total of 67,214 men participated in screening for prostate cancer (PC) using serum prostate-specific antigen (PSA) from April 1996 to March 2003 at Tokai University Hospital. In 3.5% (2,330/67,214) of the men, an elevated PSA level (>4.0 ng/ml) was found and 68.1% (1,586/2,330) of these subjects were examined at our Urological Outpatient Clinic. Re-testing of PSA showed that 8.4% (133/1,586) had a normal level. Needle biopsy of the prostate was performed in 45.2% (633/1,453) of the remaining men. As a result, 142 PCs were found and the detection rate was 0.2% (142/67,214). The age of the patients with PC was over 50 years. During this period, 135 individuals with voiding dysfunction were also diagnosed as having PC. Comparison of the patients detected by screening with those found at the outpatient clinic revealed significant differences of the age (64.8 vs. 71.9 years, p<0.0001), serum PSA level (14.6 vs. 154.9 ng/ml, p<0.0001), and clinical stage (p<0.0001). In conclusion, a health screening program that includes serum PSA testing is useful for detection of PC at an earlier stage and in younger individuals. We recommend that all men aged 50 years or older undergo testing for PSA to detect PC at an early stage.
KW - Health screening
KW - PSA
KW - Prostate cancer
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M3 - Article
C2 - 16146200
AN - SCOPUS:23944439571
SN - 0385-0005
VL - 30
SP - 103
EP - 110
JO - Tokai Journal of Experimental and Clinical Medicine
JF - Tokai Journal of Experimental and Clinical Medicine
IS - 2
ER -
