Serum bFGF levels are reduced in Japanese overweight men and restored by a 6-month exercise education

A. Seida, J. Wada, M. Kunitomi, Y. Tsuchiyama, N. Miyatake, M. Fujii, S. Kira, K. Takahashi, K. Shikata, H. Makino

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


OBJECTIVE: To investigate whether the changes in vascular endothelial growth factor (VECF) and basic fibroblast growth factor (bFCF) concentrations before and after weight reduction in Japanese overweight men are associated with changes in body mass index (BMI), visceral, subcutaneous fat, VO 2 and work rate (WR) at ventilatory threshold (VT). DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: In total, 30 Japanese overweight men (BMI, 29.0 ± 2.2 kg/m2) and 31 normal-weight men (BMI, 22.5 ± 1.6 kg/m 2) at baseline were enrolled: 30 overweight men (BMI, 29.0 ± 2.2 kg/m2) were further enrolled into a 6-month exercise program. MEASUREMENTS: Fat distribution evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, angiogenic peptides including VECF and bFCF, exercise tests at baseline and after 6 months. RESULTS: In normal-weight and overweight subjects at baseline, VEGF positively correlated with S area (r = 0.350, P = 0.007) but not with V area. In contrast, bFCF negatively correlated with BMI (r = -0.619, P<0.001), S (r = -0.457, P<0.001) and V areas (r = -0.466, P<0.001). By intervention with exercise education, 30 overweight subjects showed reduction in BMI (29.0 ± 2.2 to 28.0 ± 2.0, P<0.001), V and S areas, increase in VO2 and WR at VT, increase in bFGF (9.21 ± 5.82-21.2 ± 7.04 ng/ ml, P<0.001), and no change in VECF (1.45 ± 0.72-1.88 ± 0.52 ng/ml, P = 0.016). The stepwise multiple regression analysis revealed that ΔBMI (β = -6.052) and ΔVO2 (β = 2.806) were independently related to ΔbFCF (P<0.001) and all other variables including ΔS area, and ΔV area, and ΔWR did not enter the equation at significant levels. CONCLUSION: The present study indicated a negative correlation between serum bFCF levels and BMI at baseline as well as an association of ΔBMI and ΔVO2 with ΔbFCF after exercise intervention. The exercise-induced elevation of bFCF may be beneficial in the prevention of the atherosclerosis in overweight subjects.

Original languageEnglish
Pages (from-to)1325-1331
Number of pages7
JournalInternational Journal of Obesity
Issue number11
Publication statusPublished - Nov 2003


  • Angiogenesis
  • Atherosclerosis
  • Basic fibroblast growth factor
  • Exercise
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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