Serum C3 content in vitamin B12-deficient rats

Masahiro Wada, Tetsunori Kawata, Kazuhiro Yamada, Ulala Funada, Masanori Kuwamori, Masayoshi Endo, Nobuo Tanaka, Tadahiro Tadokoro, Akio Maekawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12 restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalInternational Journal for Vitamin and Nutrition Research
Issue number2
Publication statusPublished - Apr 27 1998


  • Serum C3
  • Vitamin B-deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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