Serum C3 content in vitamin B12-deficient rats

Masahiro Wada; Tetsunori Kawata; Kazuhiro Yamada; Ulala Funada; Masanori Kuwamori; Masayoshi Endo; Nobuo Tanaka; Tadahiro Tadokoro; Akio Maekawa

Serum C3 content in vitamin B₁₂-deficient rats

Masahiro Wada, Tetsunori Kawata, Kazuhiro Yamada, Ulala Funada, Masanori Kuwamori, Masayoshi Endo, Nobuo Tanaka, Tadahiro Tadokoro, Akio Maekawa

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

As a clue to clarifying the role of vitamin B₁₂ (B₁₂) in the function of the complement system, serum C3 content was determined in B₁₂-deficient rats, and the effect of the administration of methylcobalamin (CH₃-B₁₂) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B₁₂-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH₃-B₁₂ restored the serum C3 content to control levels. The above results indicate that B₁₂-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B₁₂-deficiency.

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	International Journal for Vitamin and Nutrition Research
Volume	68
Issue number	2
Publication status	Published - Apr 27 1998

Keywords

Serum C3
Vitamin B-deficiency

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Serum C3 content in vitamin B12-deficient rats",

abstract = "As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12 restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.",

keywords = "Serum C3, Vitamin B-deficiency",

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T1 - Serum C3 content in vitamin B12-deficient rats

AU - Wada, Masahiro

AU - Kawata, Tetsunori

AU - Yamada, Kazuhiro

AU - Funada, Ulala

AU - Kuwamori, Masanori

AU - Endo, Masayoshi

AU - Tanaka, Nobuo

AU - Tadokoro, Tadahiro

AU - Maekawa, Akio

PY - 1998/4/27

Y1 - 1998/4/27

N2 - As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12 restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.

AB - As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12 restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.

KW - Serum C3

KW - Vitamin B-deficiency

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