TY - JOUR
T1 - Serum folate and homocysteine levels are associated with colon tumorigenesis in end-stage renal disease patients
AU - Kaji, Eisuke
AU - Kato, Jun
AU - Saito, Shunsuke
AU - Harada, Keita
AU - Kuwaki, Kenji
AU - Tatsukawa, Masashi
AU - Morikawa, Tamiya
AU - Hiraoka, Sakiko
AU - Matsushima, Hiroshi
AU - Yamamoto, Kazuhide
N1 - Funding Information:
This work was supported by the Department of Gas-troenteroloy and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
PY - 2011/2
Y1 - 2011/2
N2 - The aim of this study was to evaluate the effect of folate and homocysteine on colon tumorigenesis by performing colonoscopy and examining serum folate and homocysteine levels in end-stage renal disease (ESRD) patients. We performed colonoscopy in 72 ESRD patients who were undergoing hemodialysis and also measured their serum folate and homocysteine levels. Serum folate and homocysteine concentrations of the 72 ESRD patients were 6.0 ± 3.9 μg/l and 37.3 ± 25.5 μmol/l, respectively. Colorectal neoplasia was detected in 47 (65%) of the patients. Compared to a control group, ESRD patients had significantly more and larger neoplasia (P = 0.002 and 0.001, respectively). Multivariate analysis revealed that ESRD patients with lower levels of serum homocysteine had significantly more and larger neoplasia than those with higher levels (P = 0.02 and 0.03, respectively). In addition, patients with a shorter duration of hemodialysis were likely to have larger neoplasia. ESRD patients had higher than normal serum homocysteine levels. Interestingly, patients with lower homocysteine levels were likely to carry more and larger colorectal neoplasia. These results suggest that suppression of folate metabolism and an elevated serum homocysteine concentration are inversely associated with colon tumorigenesis in ESRD patients.
AB - The aim of this study was to evaluate the effect of folate and homocysteine on colon tumorigenesis by performing colonoscopy and examining serum folate and homocysteine levels in end-stage renal disease (ESRD) patients. We performed colonoscopy in 72 ESRD patients who were undergoing hemodialysis and also measured their serum folate and homocysteine levels. Serum folate and homocysteine concentrations of the 72 ESRD patients were 6.0 ± 3.9 μg/l and 37.3 ± 25.5 μmol/l, respectively. Colorectal neoplasia was detected in 47 (65%) of the patients. Compared to a control group, ESRD patients had significantly more and larger neoplasia (P = 0.002 and 0.001, respectively). Multivariate analysis revealed that ESRD patients with lower levels of serum homocysteine had significantly more and larger neoplasia than those with higher levels (P = 0.02 and 0.03, respectively). In addition, patients with a shorter duration of hemodialysis were likely to have larger neoplasia. ESRD patients had higher than normal serum homocysteine levels. Interestingly, patients with lower homocysteine levels were likely to carry more and larger colorectal neoplasia. These results suggest that suppression of folate metabolism and an elevated serum homocysteine concentration are inversely associated with colon tumorigenesis in ESRD patients.
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U2 - 10.1080/01635581.2011.523501
DO - 10.1080/01635581.2011.523501
M3 - Article
C2 - 21264789
AN - SCOPUS:79951929509
SN - 0163-5581
VL - 63
SP - 202
EP - 211
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 2
ER -
