Serum interleukin-18 levels are associated with physical activity in Japanese men

Kanae Oda, Nobuyuki Miyatake, Noriko Sakano, Takeshi Saito, Motohiko Miyachi, Izumi Tabata, Takeyuki Numata

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objective: To investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men. Methods: A total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study. We assessed anthropometric and body composition parameters. Serum IL-18 levels, physical activity by uniaxial accelerometers, peak oxygen uptake and metabolic risk parameters were also evaluated. Results: Serum IL-18 levels were 179.4±84.7 pg/mL. Physical activity evaluated by ∑[metabolic equivalents x h per week (METs·h/w)]was significantly and negatively correlated with serum IL-18 levels (r = -0.252, p = 0.0235). These associations remained even after adjusting for age, peak oxygen uptake and other confounding factors. Conclusion: Serum IL-18 levels were closely associated with physical activity independent of peak oxygen uptake in Japanese men.

Original languageEnglish
Article numbere81497
JournalPloS one
Issue number12
Publication statusPublished - Dec 11 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General


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