TY - JOUR
T1 - Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma
AU - Nishimura, Mamoru
AU - Takaki, Akinobu
AU - Tamaki, Naofumi
AU - Maruyama, Takayuki
AU - Onishi, Hideki
AU - Kobayashi, Sayo
AU - Nouso, Kazuhiro
AU - Yasunaka, Tetsuya
AU - Koike, Kazuko
AU - Hagihara, Hiroaki
AU - Kuwaki, Kenji
AU - Nakamura, Shinichiro
AU - Ikeda, Fusao
AU - Iwasaki, Yoshiaki
AU - Tomofuji, Takaaki
AU - Morita, Manabu
AU - Yamamoto, Kazuhide
PY - 2013/10
Y1 - 2013/10
N2 - Aim: Oxidative stress is associated with progression of chronic liver disease (CLD). This association is best established in chronic hepatitis C. However, the anti-oxidative state is not well characterized. The objective of the present study was to investigate the balance of oxidative and anti-oxidative stress in CLD patients. Methods: We recruited a study population of 208 patients, including healthy volunteers (HV; n=15), patients with hepatitis B virus (HBV)-related CLD without or with hepatocellular carcinoma (HBV-non-HCC, n=25, and HBV-HCC, n=50, respectively), and patients with hepatitis C virus (HCV)-related CLD without or with HCC (HCV-non-HCC, n=49, and HCV-HCC, n=69, respectively). Serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY-adsorbent test; OXY) were determined, and the balance of these values was used as the oxidative index. Correlations among ROM, OXY, oxidative index and clinical characteristics were investigated. Results: Patients with CLD exhibited elevated ROM and oxidative index compared to HV. Among patients with CLD, HCV positive status correlated with increased ROM. In CLD, HCV-HCC patients exhibited the highest ROM levels. Among HCV-related CLD patients, lower OXY correlated with HCC positive status, but was recovered by eradication of HCC. In HCV-HCC, lower OXY correlated with high PT-INR. Conclusion: HCV positive CLD patients displayed higher oxidative stress and HCV-HCC patients displayed lower anti-oxidative state. Anti-oxidative state depression was associated with liver reservoir-related data in HCV-HCC and could be reversed with HCC eradication.
AB - Aim: Oxidative stress is associated with progression of chronic liver disease (CLD). This association is best established in chronic hepatitis C. However, the anti-oxidative state is not well characterized. The objective of the present study was to investigate the balance of oxidative and anti-oxidative stress in CLD patients. Methods: We recruited a study population of 208 patients, including healthy volunteers (HV; n=15), patients with hepatitis B virus (HBV)-related CLD without or with hepatocellular carcinoma (HBV-non-HCC, n=25, and HBV-HCC, n=50, respectively), and patients with hepatitis C virus (HCV)-related CLD without or with HCC (HCV-non-HCC, n=49, and HCV-HCC, n=69, respectively). Serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY-adsorbent test; OXY) were determined, and the balance of these values was used as the oxidative index. Correlations among ROM, OXY, oxidative index and clinical characteristics were investigated. Results: Patients with CLD exhibited elevated ROM and oxidative index compared to HV. Among patients with CLD, HCV positive status correlated with increased ROM. In CLD, HCV-HCC patients exhibited the highest ROM levels. Among HCV-related CLD patients, lower OXY correlated with HCC positive status, but was recovered by eradication of HCC. In HCV-HCC, lower OXY correlated with high PT-INR. Conclusion: HCV positive CLD patients displayed higher oxidative stress and HCV-HCC patients displayed lower anti-oxidative state. Anti-oxidative state depression was associated with liver reservoir-related data in HCV-HCC and could be reversed with HCC eradication.
KW - Anti-oxidant
KW - Chronic hepatitis C
KW - Hepatocellular carcinoma
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84885040020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885040020&partnerID=8YFLogxK
U2 - 10.1111/hepr.12048
DO - 10.1111/hepr.12048
M3 - Article
C2 - 23363268
AN - SCOPUS:84885040020
SN - 1386-6346
VL - 43
SP - 1078
EP - 1092
JO - Hepatology Research
JF - Hepatology Research
IS - 10
ER -
