Serum total cholesterol of new students enrolled at Okayama University: Trend during 1989-1998

Toshio Ogura, Kazuharu Matsuura, Hisao Suzuki, Masayuki Kishida, Satoru Ikeda, Chiaki Tsukamoto, Ayumi Imai, Kazuo Tobe

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


To clarify the trend of hypercholesterolemia in Japanese adolescents, we investigated the serial changes in body mass index (BMI) and serum total cholesterol (TC) concentrations among 5,700 new students enrolled at Okayama University in 1989, 1993, and 1998. After confirming the stability of the TC assay of serum samples stored at -80°C, we measured serum TC levels in stored serum samples using an automated assay system. Although serum TC levels were higher in females than in males, these levels correlated weakly and positively with BMI (r = 0.21, P < 0.001) in males but not in females. Serum TC concentrations progressively increased from 1989-1998 in both sexes, irrespective of changes in BMI. In subjects with normal BMI (≥19 and <23 kg/m2), a significant increase in serum TC was noted from 1989-1998 in both males (157.2±1.0 to 163.6±0.9 mg/dl) and females (172.0±1.1 to 175.6±1.0 mg/dl). Our results indicate on increased incidence of hypercholesterolemia even in nonobese young Japanese adolescents. A concerted effort by health and education officials together with parents is necessary to prevent a further rise in the incidence of hypercholesterolemia among young Japanese.

Original languageEnglish
Pages (from-to)269-276
Number of pages8
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2001


  • Adolescent
  • Body mass index
  • Lifestyle-related disease
  • Masked obesity

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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