Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice

K. Watanabe; T. Matsunaga; S. Narimatsu; I. Yamamoto; H. Yoshimura

Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice

K. Watanabe, T. Matsunaga, S. Narimatsu, I. Yamamoto, H. Yoshimura

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Hepatic microsomal oxidation of 11-oxo-Δ⁸-tetrahydrocannabinol (11-oxo- Δ⁸-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ⁸-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ⁸-THC.

Original language	English
Pages (from-to)	373-376
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	78
Issue number	3
Publication status	Published - Dec 1 1992

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice",

abstract = "Hepatic microsomal oxidation of 11-oxo-Δ8-tetrahydrocannabinol (11-oxo- Δ8-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ8-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ8-THC.",

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T1 - Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice

AU - Watanabe, K.

AU - Matsunaga, T.

AU - Narimatsu, S.

AU - Yamamoto, I.

AU - Yoshimura, H.

PY - 1992/12/1

Y1 - 1992/12/1

N2 - Hepatic microsomal oxidation of 11-oxo-Δ8-tetrahydrocannabinol (11-oxo- Δ8-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ8-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ8-THC.

AB - Hepatic microsomal oxidation of 11-oxo-Δ8-tetrahydrocannabinol (11-oxo- Δ8-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ8-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ8-THC.

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Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice

Abstract

ASJC Scopus subject areas

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