TY - JOUR
T1 - Significance of adrenomedullin under cardiopulmonary bypass in children during surgery for congenital heart disease
AU - Takeuchi, Mamoru
AU - Morita, Kiyoshi
AU - Iwasaki, Tatsuo
AU - Toda, Yuichiro
AU - Oe, Katsunori
AU - Taga, Naoyuki
AU - Hirakawa, Masahisa
PY - 2001/12/1
Y1 - 2001/12/1
N2 - To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P < 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis.
AB - To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P < 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis.
KW - Adrenomedullin
KW - Brain natriuretic peptide
KW - Cardiopulmonary bypass
KW - Pediatric cardiac surgery
KW - Vasopressin
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UR - http://www.scopus.com/inward/citedby.url?scp=0035430822&partnerID=8YFLogxK
M3 - Article
C2 - 11512567
AN - SCOPUS:0035430822
SN - 0386-300X
VL - 55
SP - 245
EP - 252
JO - Acta medica Okayama
JF - Acta medica Okayama
IS - 4
ER -