Significance of des-gamma-carboxy prothrombin production in hepatocellular carcinoma

Tatsuya Fujikawa, Hidenori Shiraha, Kazuhide Yamamoto

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


Serum des-γ-carboxy prothrombin (DCP) is commonly used to detect hepatocellular carcinoma (HCC). This review focuses on the clinical features of DCP-positive HCC and the molecular function of DCP in HCC. DCP-positive HCC demonstrates more aggressive clinicopathological features than DCP-negative HCC. Analysis of the biological effects of DCP revealed that DCP acts as a growth factor in both an autocrine and paracrine manner. DCP stimulates HCC cell proliferation through the Met-Janus kinase 1-signal transducer and activator of transcription 3 signaling pathway, whereas for vascular endothelial cells, it stimulates cell proliferation and migration through the kinase insert domain receptor-phospholipase C-γ-mitogen-activated protein kinase signaling pathway.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalActa medica Okayama
Issue number6
Publication statusPublished - Dec 2009


  • Angiogenesis
  • Cell proliferation
  • Des-γ-carboxy prothrombin
  • Hepatocellular carcinoma
  • Signaling pathway

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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