Significance of estimating the glomerular filtration rate for the management of hypertension in type 2 diabetes with microalbuminuria

Motonobu Nishimura, Yasuhisa Kato, Tsuyoshi Tanaka, Ryohei Todo, Atsuhito Tone, Kazunori Yamada, Sumire Ootani, Yojiro Kawabe, Hideyuki Yoshizumi, Yoshiharu Hoshiyama

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The Home Blood Pressure for Diabetic Nephropathy (HBP-DN) study is a prospective cohort study to determine the optimal home blood pressure (HBP) required to improve the prognosis of type 2 diabetic patients with microalbuminuria. The glomerular filtration rate (GFR) is heterogeneous in microalbuminuric diabetic patients. The first step of the HBP-DN study explored the significance of estimating GFR for the identification of patients for whom HBP measurement would be more helpful. The patients were divided into two groups based on their estimated GFR (eGFR): a low eGFR group (eGFR <60 ml min -1 per 1.73 m2, N=75) and a preserved eGFR group (eGFR ≥60 ml min-1 per 1.73 m2, N=193). HBP, variability of HBP and a previous history of vascular complications were compared between the two groups. The number of antihypertensive drugs used for the patients and the s.d. of home systolic blood pressure (HSBP) in the low eGFR group were significantly higher than those in the preserved eGFR group. A stepwise multiple linear regression analysis also revealed that the low eGFR group was independently correlated with the s.d. of HSBP. A multiple logistic regression analysis revealed that a low eGFR was an independent risk factor for coronary heart disease and advanced retinopathy. Estimating the GFR is important to identify patients with elevated blood pressure variability, as well as those with a high risk of vascular complications. Measuring HBP would be more helpful for the effective and safe treatment of hypertension in patients with a low eGFR than in those with a preserved eGFR.

Original languageEnglish
Pages (from-to)705-710
Number of pages6
JournalHypertension Research
Issue number8
Publication statusPublished - Aug 2013


  • blood pressure variability
  • diabetic nephropathy
  • estimated glomerular filtration rate
  • home blood pressure
  • microalbuminuria

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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