TY - JOUR
T1 - Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents
AU - Iwasa, Kinuko
AU - Moriyasu, Masataka
AU - Tachibana, Yoko
AU - Kim, Hye Sook
AU - Wataya, Yusuke
AU - Wiegrebe, Wolfgang
AU - Bastow, Kenneth F.
AU - Cosentino, L. Mark
AU - Kozuka, Mutsuo
AU - Lee, Kuo Hsiung
N1 - Funding Information:
This work was supported by a Grants-in-Aid for Scientific Research on Priority Areas (08281105) from the Ministry of Education, Science, Culture, and Sports, Japan awarded to Y. Wataya and, in part, by grants from the National Cancer Institute (CA 17625) and from the National Institute of Allergy and Infectious Diseases (AI 33066) awarded to K. H. Lee.
PY - 2001
Y1 - 2001
N2 - Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simple isoquinoline alkaloids were significantly active in each assay, and may be useful as lead compounds for developing potential chemotherapeutic agents. These compounds include 13 (antimicrobial), 25, 26, and 42 (antimalarial), 13 and 25 (cytotoxic), and 28 and 29 (anti-HIV). A quaternary nitrogen atom of isoquinolium or dihydroisoquinolinium type may contribute to enhanced potency in the first three types of activities. In contrast , anti-HIV activity was found with tetrahydroisoquinoline and 6,7-dihydroxyisoquinolium salts.
AB - Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simple isoquinoline alkaloids were significantly active in each assay, and may be useful as lead compounds for developing potential chemotherapeutic agents. These compounds include 13 (antimicrobial), 25, 26, and 42 (antimalarial), 13 and 25 (cytotoxic), and 28 and 29 (anti-HIV). A quaternary nitrogen atom of isoquinolium or dihydroisoquinolinium type may contribute to enhanced potency in the first three types of activities. In contrast , anti-HIV activity was found with tetrahydroisoquinoline and 6,7-dihydroxyisoquinolium salts.
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U2 - 10.1016/S0968-0896(01)00154-7
DO - 10.1016/S0968-0896(01)00154-7
M3 - Article
C2 - 11597468
AN - SCOPUS:0034800793
SN - 0968-0896
VL - 9
SP - 2871
EP - 2884
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 11
ER -
