TY - GEN
T1 - Simulation study on the effect of fiber loss to the compound action potential of a sural nerve
AU - Hayami, Takehito
AU - Iramina, Keiji
AU - Chen, Xian
AU - Sunagawa, Kenji
PY - 2007/12/1
Y1 - 2007/12/1
N2 - This paper reports the result of computer simulation about compound action potential of a sural nerve with and without fiber loss. A compound action potential is a wave of electric potential detectable on the skin after electric stimulation of a peripheral nerve. The loss of nerve fibers, which is observed in some neuropathies, is considered as the cause of low amplitude and slow conduction of the wave. To quantify the relationship between fiber loss and compound action potential, computer simulation of the stimulation of a human sural nerve was executed. As a result, the conduction velocity of the first negative peak of the compound action potential was substantially reduced in case of thick fiber loss, and was slightly enlarged in case of thin fiber loss. However the amplitude of the peak was not always reduced. The effect of thin fiber loss was observed in the amplitude of the second positive peak and the second negative peak.
AB - This paper reports the result of computer simulation about compound action potential of a sural nerve with and without fiber loss. A compound action potential is a wave of electric potential detectable on the skin after electric stimulation of a peripheral nerve. The loss of nerve fibers, which is observed in some neuropathies, is considered as the cause of low amplitude and slow conduction of the wave. To quantify the relationship between fiber loss and compound action potential, computer simulation of the stimulation of a human sural nerve was executed. As a result, the conduction velocity of the first negative peak of the compound action potential was substantially reduced in case of thick fiber loss, and was slightly enlarged in case of thin fiber loss. However the amplitude of the peak was not always reduced. The effect of thin fiber loss was observed in the amplitude of the second positive peak and the second negative peak.
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U2 - 10.1109/IEMBS.2007.4352810
DO - 10.1109/IEMBS.2007.4352810
M3 - Conference contribution
C2 - 18002476
AN - SCOPUS:57649170821
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 2396
EP - 2399
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -