TY - JOUR
T1 - Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests
AU - Kawahara, Yuko
AU - Ikeda, Yoshio
AU - Deguchi, Kentaro
AU - Kurata, Tomoko
AU - Hishikawa, Nozomi
AU - Sato, Kota
AU - Kono, Syoichiro
AU - Yunoki, Taijun
AU - Omote, Yosio
AU - Yamashita, Toru
AU - Abe, Koji
N1 - Funding Information:
This study was partially supported by a Grant-in-Aid for Scientific Research (B) 21390267 and the Ministry of Education, Science, Culture and Sports of Japan , and by grants (Sobue G, Nishizawa M, Sasaki H, Mizusawa H, and Nakano I) from the Ministry of Health, Labour and Welfare of Japan . We are grateful to S. Kametaka, M. Osafune, M. Muraoka, and Y. Yabunaka for their technical assistance.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/4/15
Y1 - 2015/4/15
N2 - Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n = 25), MSA with predominant parkinsonism (MSA-P, n = 8), and CCA (n = 14) patients using computerized touch panel screening tests. Mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), frontal assessment battery (FAB), and Montreal cognitive assessment (MoCA) scores were significantly lower in MSA-C patients than in age-and gender-matched normal controls. One MSA-C patient showed a decrease in the regional cerebral blood flow (rCBF) of the frontal lobe. MSA-P patients showed no such cognitive decline. Only FAB and MoCA scores were significantly lower in the CCA patients. MSA and CCA patients also showed a mild to moderate depressive state. Touch-panel screening tests demonstrated a significant decline of beating devils game in all three disease groups including MSA-P patients, and a significant extension of the flipping cards game only in MSA-C patients. The present study demonstrated different cognitive and affective functions among MSA-C, MSA-P, and CCA patients, and a sensitive screening method for cognitive assessment using touch-panel tests.
AB - Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n = 25), MSA with predominant parkinsonism (MSA-P, n = 8), and CCA (n = 14) patients using computerized touch panel screening tests. Mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), frontal assessment battery (FAB), and Montreal cognitive assessment (MoCA) scores were significantly lower in MSA-C patients than in age-and gender-matched normal controls. One MSA-C patient showed a decrease in the regional cerebral blood flow (rCBF) of the frontal lobe. MSA-P patients showed no such cognitive decline. Only FAB and MoCA scores were significantly lower in the CCA patients. MSA and CCA patients also showed a mild to moderate depressive state. Touch-panel screening tests demonstrated a significant decline of beating devils game in all three disease groups including MSA-P patients, and a significant extension of the flipping cards game only in MSA-C patients. The present study demonstrated different cognitive and affective functions among MSA-C, MSA-P, and CCA patients, and a sensitive screening method for cognitive assessment using touch-panel tests.
KW - Affective disorder
KW - Cognitive impairment
KW - Cortical cerebellar atrophy
KW - Multiple system atrophy
KW - Regional cerebral blood flow
KW - Touch panel screening test
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U2 - 10.1016/j.jns.2015.02.010
DO - 10.1016/j.jns.2015.02.010
M3 - Article
C2 - 25727351
AN - SCOPUS:84926420244
SN - 0022-510X
VL - 351
SP - 24
EP - 30
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 1-2
ER -