Abstract
The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80% occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.
| Original language | English |
|---|---|
| Pages (from-to) | 511-514 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 192-195 |
| Publication status | Published - 2001 |
| Event | 13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy Duration: Nov 22 2000 → Nov 26 2000 |
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering