Skin sympathetic outflow in Buerger's disease

Satoshi Iwase, Tetsuya Okamoto, Tadaaki Mano, Atsunori Kamiya, Yuki Niimi, Fu Qi, Naomichi Nishikimi, Tsunehisa Sakurai, Yuji Nimura

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


To clarify if sympathetic outflow is altered in Buerger's disease (thromboangitis obliterans, TAO), we measured skin sympathetic nerve activity (SSNA) in TAO patients, and observed the sweating and vasoconstrictive responses during resting and with activating maneuvers. Multiunit postganglionic sympathetic activity was recorded in a skin fascicle of the tibial nerve innervating the skin of the sole (glabrous skin) and peroneal nerve innervating the skin of the dorsum pedis (hairy skin) from five TAO patients and five healthy subjects simultaneously with skin blood flow and sweat expulsion. TAO patients showed significantly less vasoconstrictor SSNA than healthy subjects (17.0±1.9 vs. 31.5±5.8 bursts/min, P<0.001). Moreover, we found no relationship between vasoconstrictor SSNA and skin blood flow in some patients, while they were well correlated in healthy subjects. There was no evidence for increased sympathetic activity in TAO patients, and no hypersensitive relationship was found between SSNA and skin blood flow. These observations suggested that these TAO patients exhibiting no relationship between skin blood flow reduction and vasoconstrictor activity might not respond to sympathectomy, which is generally expected to result in an increase in skin blood flow. The absence of increased sympathetic nerve activity provides further indirect evidence of a local vascular abnormality in TAO.

Original languageEnglish
Pages (from-to)286-292
Number of pages7
JournalAutonomic Neuroscience: Basic and Clinical
Issue number2-3
Publication statusPublished - Mar 23 2001
Externally publishedYes


  • Buerger's disease
  • Microneurography
  • Skin blood flow
  • Skin sympathetic nerve activity
  • Sweat expulsion

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Skin sympathetic outflow in Buerger's disease'. Together they form a unique fingerprint.

Cite this