Sleep quality and its association with health-related quality of life of patients on lung transplantation waitlist in Japan

Junko Tokuno, Toru Oga, Toyofumi F. Chen-Yoshikawa, Takahiro Oto, Tomoyo Okawa, Yoshinori Okada, Miki Akiba, Masaki Ikeda, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Maki Isomi, Kazuo Chin, Hiroshi Date

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose: Poor quality of sleep is a common feature in patients with various lung diseases and affects their health-related quality of life (HRQL). We evaluated sleep quality and HRQL in patients on the waitlist for lung transplantation in Japan. Methods: In this prospective study, patient-reported and physiological data were collected from patients newly registered on the waitlist for lung transplantation in Japan. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) and HRQL using the St. George’s Respiratory Questionnaire (SGRQ). The frequency of poor sleep quality, correlations between sleep quality and various clinical parameters, and predictive factors of sleep quality were examined. Results: Of 193 patients, the three most-frequent indications for lung transplantation were interstitial pneumonia (n = 96), pulmonary complications of hematopoietic stem cell transplantation (n = 25), and pulmonary hypertension (n = 17). Poor sleep quality (PSQI > 5) was observed in 102 patients (53%) and was significantly associated with worse Hospital Anxiety and Depression Score (HADS), worse SGRQ score, worse modified Medical Research Council Dyspnea score, and shorter 6-min walk distance. However, it was not associated with sex, pulmonary function, interstitial pneumonia, or arterial blood gas. Stepwise multiple regression analysis indicated that poor sleep quality was explained significantly by HADS anxiety (23%) and SGRQ Symptoms (10%). Conclusion: Poor sleep quality was found to be common among patients on the lung transplantation waitlist in Japan. The two most significant factors responsible for impaired sleep quality were anxiety and respiratory symptoms. Additional care should be taken to ensuring a better quality of sleep for such patients.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalSleep and Breathing
Issue number1
Publication statusPublished - Mar 2021


  • Health-related quality of life (HRQL)
  • Lung transplantation
  • Pittsburgh Sleep Quality Index (PSQI)
  • Sleep quality
  • St. George’s Respiratory Questionnaire (SGRQ)

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology


Dive into the research topics of 'Sleep quality and its association with health-related quality of life of patients on lung transplantation waitlist in Japan'. Together they form a unique fingerprint.

Cite this