Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels

K. Tsuru; Z. Robertson; B. Annaz; I. R. Gibson; S. M. Best; Y. Shirosaki; S. Hayakawa; A. Osaka

Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels

K. Tsuru, Z. Robertson, B. Annaz, I. R. Gibson, S. M. Best, Y. Shirosaki, S. Hayakawa, A. Osaka

Research output: Contribution to journal › Article › peer-review

Abstract

Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(TV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.

Original language	English
Pages (from-to)	447-450
Number of pages	4
Journal	Key Engineering Materials
Volume	361-363 I
Publication status	Published - Jan 1 2008

Keywords

Biodegradability
Cell-material interactions
Organic-inorganic hybrids
Scaffolds
Tissue engineering

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels",

abstract = "Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(TV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.",

keywords = "Biodegradability, Cell-material interactions, Organic-inorganic hybrids, Scaffolds, Tissue engineering",

author = "K. Tsuru and Z. Robertson and B. Annaz and Gibson, {I. R.} and Best, {S. M.} and Y. Shirosaki and S. Hayakawa and A. Osaka",

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T1 - Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels

AU - Tsuru, K.

AU - Robertson, Z.

AU - Annaz, B.

AU - Gibson, I. R.

AU - Best, S. M.

AU - Shirosaki, Y.

AU - Hayakawa, S.

AU - Osaka, A.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(TV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.

AB - Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(TV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.

KW - Biodegradability

KW - Cell-material interactions

KW - Organic-inorganic hybrids

KW - Scaffolds

KW - Tissue engineering

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M3 - Article

AN - SCOPUS:38148998817

SN - 1013-9826

VL - 361-363 I

SP - 447

EP - 450

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels

Abstract

Keywords

ASJC Scopus subject areas

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