Soluble interleukin-2 receptor as an indicator of immunological disturbance found in silicosis patients

H. Hayashi, M. Maeda, S. Murakami, N. Kumagai, Y. Chen, T. Hatayama, M. Katoh, N. Miyahara, S. Yamamoto, Y. Yoshida, Y. Nishimura, M. Kusaka, W. Fujimoto, Takemi Otsuki

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17 Citations (Scopus)


Silicosis patients (SILs) possess not only respiratory disorders but also alterations in autoimmunity. To determine an early indicator of immunological disturbance in SILs, the role of serum-soluble interleukin (IL)-2 receptor (sIL-2R) was analyzed. Of ten SlLs, immunological clinical parameters such as immunoglobulin (Ig) G, complements, the titer of autoantibodies including anti-nuclear antibodies (ANA), anti-Scl-70 antibody (Ab) and anti-centromere (CM) Ab, and experimental indicators such as serum-soluble Fas, serum IL-2, CD25+ cells in CD4+ or CD8+ fractions, and sIL-2R were divided from respiratory parameters such as % vital capacity (%VC), percentage of forced expiratory volume in 1 second (FEV1.0%) and v25/Ht (liter/second/m(body height) by a correlation assay. Additionally, a stepwise regression test showed that sIL-2R was correlated with Ig G, ANA and anti-CM Ab. Furthermore, factor analysis revealed that sIL-2R contributed to the subpopulation of SILs with poorer immunological status in the absence of alterations in respiratory status. By defining healthy donors as 1, SILs as 2 and patients with systemic sclerosis as 3 for immunopathological progression status as metric variables, sIL2R and ANA showed a strong positive correlation. This suggests that sIL-2R is a good clinical indicator of immunological disturbance found in SILs without clinical manifestations of any disturbance in autoimmunity. Further analysis using a large-scale number of patients should be performed to confirm these findings.

Original languageEnglish
Pages (from-to)53-62
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Issue number1
Publication statusPublished - Jan 2009
Externally publishedYes


  • Autoimmune diseases
  • SIL-2R
  • Silicosis
  • Systemic sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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