TY - JOUR
T1 - Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth
AU - Iseki, Sachiko
AU - Araga, Akihiro
AU - Ohuchi, Hideyo
AU - Nohno, Tsutomu
AU - Yoshioka, Hidefumi
AU - Hayashi, Fumio
AU - Noji, Sumihare
N1 - Funding Information:
This work was supported by grants from the Ministry of Education, Science and Culture of Japan.
PY - 1996/1/26
Y1 - 1996/1/26
N2 - Sonic hedgehog (Shh) is a vertebrate gene homologous to a Drosophila segment polarity gene, hedgehog, and functions as a secreted signaling molecule in limb pattern formation, differentiation of motor neurons, and sclerotome induction. We found that Shh is also expressed in epithelia of the developing whisker, hair, tooth, rugae, and thyroid primordium of mouse embryos. In whisker and hair development, Shh is expressed in epithelial cells before condensation of the underlying mesenchymal cells and then in the placode. The expression of Shh continues in the hair bulb surrounding the dermal papilla. Shh is also expressed in epithelial cells of the tooth bud, then localized to the enamel knot. The Shh expression continues in developing ameloblasts. These results suggest that SHH is an essential epithelial signaling molecule in epithelio-mesenchymal interactions for the terminal differentiation.
AB - Sonic hedgehog (Shh) is a vertebrate gene homologous to a Drosophila segment polarity gene, hedgehog, and functions as a secreted signaling molecule in limb pattern formation, differentiation of motor neurons, and sclerotome induction. We found that Shh is also expressed in epithelia of the developing whisker, hair, tooth, rugae, and thyroid primordium of mouse embryos. In whisker and hair development, Shh is expressed in epithelial cells before condensation of the underlying mesenchymal cells and then in the placode. The expression of Shh continues in the hair bulb surrounding the dermal papilla. Shh is also expressed in epithelial cells of the tooth bud, then localized to the enamel knot. The Shh expression continues in developing ameloblasts. These results suggest that SHH is an essential epithelial signaling molecule in epithelio-mesenchymal interactions for the terminal differentiation.
UR - http://www.scopus.com/inward/record.url?scp=0030044489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030044489&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1996.0123
DO - 10.1006/bbrc.1996.0123
M3 - Article
C2 - 8579575
AN - SCOPUS:0030044489
SN - 0006-291X
VL - 218
SP - 688
EP - 693
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -