Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth

Sachiko Iseki, Akihiro Araga, Hideyo Ohuchi, Tsutomu Nohno, Hidefumi Yoshioka, Fumio Hayashi, Sumihare Noji

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


Sonic hedgehog (Shh) is a vertebrate gene homologous to a Drosophila segment polarity gene, hedgehog, and functions as a secreted signaling molecule in limb pattern formation, differentiation of motor neurons, and sclerotome induction. We found that Shh is also expressed in epithelia of the developing whisker, hair, tooth, rugae, and thyroid primordium of mouse embryos. In whisker and hair development, Shh is expressed in epithelial cells before condensation of the underlying mesenchymal cells and then in the placode. The expression of Shh continues in the hair bulb surrounding the dermal papilla. Shh is also expressed in epithelial cells of the tooth bud, then localized to the enamel knot. The Shh expression continues in developing ameloblasts. These results suggest that SHH is an essential epithelial signaling molecule in epithelio-mesenchymal interactions for the terminal differentiation.

Original languageEnglish
Pages (from-to)688-693
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Jan 26 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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