Sonographic diagnosis for Mikulicz disease

Mayumi Shimizu, Masafumi Moriyama, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, Tazuko K. Goto, Yukiko Ohyama, Seiji Nakamura, Kazunori Yoshiura

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Objective: The aim was to investigate the diagnostic imaging characteristics of Mikulicz disease (MD), especially sonographic ones, and to clarify the differences between them and those in Sjögren syndrome (SS), based on new criteria of MD. Study design: The sonographic and sialographic images, as well as clinical, histopathologic, and serologic findings of 9 patients satisfying the new criteria of MD were analyzed and compared with those in SS. Results: All swollen submandibular glands showed bilateral nodal hypoechoic areas with high vascularization on sonograms and a parenchymal defect on sialograms, whereas parotid glands showed normal or slight change on both images. Nodal areas in submandibular gland sonograms were unclear on computerized tomography and on magnetic resonance imaging, but showed accumulation on gallium scintigraphy. Conclusion: Mikulicz disease showed a high rate of bilateral nodal change in submandibular glands, which was completely different from SS. For detection and follow-up of these changes, sonography may be the best imaging modality.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Issue number1
Publication statusPublished - Jul 2009
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • General Dentistry


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