Spastic paraplegia accompanied by extrapyramidal sign and frontal cognitive dysfunction

Ryo Sasaki, Yasuyuki Ohta, Kota Sato, Koh Tadokoro, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hiroyuki Ishiura, Shoji Tsuji, Koji Abe

Research output: Contribution to journalArticlepeer-review


A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging.

Original languageEnglish
Pages (from-to)3163-3165
Number of pages3
JournalInternal Medicine
Issue number21
Publication statusPublished - 2019


  • Extrapyramidal sign
  • Frontal cognitive dysfunction
  • Spastic paraplegia

ASJC Scopus subject areas

  • Internal Medicine


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