Stage of hepatocellular carcinoma is associated with periodontitis

Naofumi Tamaki, Akinobu Takaki, Takaaki Tomofuji, Yasumasa Endo, Kenta Kasuyama, Daisuke Ekuni, Tetsuya Yasunaka, Kazuhide Yamamoto, Manabu Morita

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Aim Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis. Material and Methods We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels. Results The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p < 0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p < 0.001). Conclusion HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
JournalJournal of Clinical Periodontology
Issue number11
Publication statusPublished - Nov 2011


  • JIS score
  • anti-oxidant
  • carcinoma, hepatocellular
  • oxidative stress
  • periodontitis

ASJC Scopus subject areas

  • Periodontics


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