Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction

Rui Guo, Masatoshi Morimatsu, Tian Feng, Feng Lan, Dehua Chang, Feng Wan, Yunpeng Ling

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.

Original languageEnglish
Article number19
JournalStem Cell Research and Therapy
Issue number1
Publication statusPublished - Jan 8 2020


  • Angiogenesis
  • Cardiac tissue
  • Cell sheet
  • Cell therapy
  • Heart failure
  • Inflammation
  • Mesenchymal stem cells
  • Myocardial infarction
  • Pluripotent stem cells
  • Skeletal myoblasts

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Cell Biology


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