Abstract
Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.
| Original language | English |
|---|---|
| Article number | 19 |
| Journal | Stem Cell Research and Therapy |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 8 2020 |
Keywords
- Angiogenesis
- Cardiac tissue
- Cell sheet
- Cell therapy
- Heart failure
- Inflammation
- Mesenchymal stem cells
- Myocardial infarction
- Pluripotent stem cells
- Skeletal myoblasts
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Cell Biology